The enhancement of antibody response by IgM antibodies is dependent on antigen-specific T helper cells

Immunobiology
A Coutinho, L Forni

Abstract

The enhancement of antibody responses by IgM antibodies administered with low doses of antigen has been studied in a T-dependent (SRBC) and an T-independent (alpha 1,6 dextran) system. It has been found that IgM anti-SRBC antibodies do not enhance a SRBC response in nude mice. The T-cell dependency was also directly demonstrated by showing the effect of IgM on T-cell priming in transfer experiments. The simultaneous injection of antigen and IgM antibody also induced a polyclonal increase of IgM, PFC, which was not due to a non-specific "adjuvant" effect of IgM, as we could not detect a similar effect on an ongoing response to HRBC in mice simultaneously given SRBC and IgM anti-SRBC antibodies. The specificity of the helper cell for either the antibody or the antigen was investigated in a response to alpha 1, 6 dextran, in which we could demonstrate antibody-specific helper T cells, but no antigen-specific help. We have found that IgM anti-dextran antibodies do not enhance and rather suppress the response of normal, high-responder mice, to dextran, suggesting that the T cells mediating the "19S enhancement" are antigen-specific. The magnitude of the enhancement response, as compared to the responses induced by either antigen or ...Continue Reading

References

Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C A JanewayH N Eisen
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C A JanewayH Wigzell
Aug 18, 1977·Nature·J M Phillips, H Waldmann
Jan 1, 1975·European Journal of Immunology·C A JanewayW E Paul
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 1, 1980·International Archives of Allergy and Applied Immunology·M H Schreier, R Tees
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L ForniN K Jerne

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Citations

Jan 1, 1982·Immunobiology·D HolmbergA Coutinho
Jan 1, 1986·Cellular Immunology·J ReiterA Cooke
Mar 1, 1985·Scandinavian Journal of Immunology·B Heyman, H Wigzell

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