The enhancement of carbachol-induced salivary secretion by VIP and CGRP in rat parotid gland is mimicked by forskolin.

Acta Physiologica Scandinavica
O Larsson, L Olgart

Abstract

Low doses of vasoactive intestinal polypeptide (VIP) and calcitonin gene-related peptide (CGRP) have been shown to augment the salivary volume secretion evoked by muscarinic receptor agonists or substance P (SP) in rat parotid gland. Since VIP and CGRP are known to activate adenylate cyclase, we have studied whether forskolin, which directly activates this enzyme, can mimic the effects of these peptides on salivary secretion from the parotid gland in anaesthetized (Inactin 0.5 g kg-1 i.p.) rats. We have also studied the effect of the secretagogues and peptides on glandular blood flow as revealed by the laser Doppler technique. Carbachol (5 nmol kg-1) and SP (185 pmol kg-1) injected i.v. caused a transient increase in parotid blood flow and a decrease in systematic blood pressure concomitant with a salivary secretion of 3.3 +/- 0.3 mg (n = 22) and 18.7 +/- 1.9 mg (n = 25) respectively. VIP (150 pmol kg-1) and CGRP (25 pmol kg-1) also caused a transient increase in glandular blood flow concomitant with a decrease in systemic blood pressure, but no salivary secretion. The glandular blood flow increased by 166 +/- 5% and 43 +/- 11% for VIP and CGRP respectively. When carbachol was given 20 s after the injection of VIP or CGRP, the ...Continue Reading

References

Apr 1, 1986·Acta Physiologica Scandinavica·M Dunér-EngströmB B Fredholm
Mar 1, 1988·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J EkströmG Tobin
Dec 1, 1986·Clinical Endocrinology·S SchifterH H Hansen
Jan 1, 1982·Acta Physiologica Scandinavica·B B Fredholm, J M Lundberg

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Citations

Oct 24, 2003·Cell Calcium·Jason I E BruceDavid I Yule
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
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Aug 18, 2020·Disease Models & Mechanisms·Shohei YoshimotoShuichi Hashimoto
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Oct 9, 2002·The Journal of Biological Chemistry·Jason I E BruceTrevor J Shuttleworth
Dec 23, 2021·Journal of Clinical Pharmacy and Therapeutics·Pablo Selvi-SabaterFrancisco Javier Carrera-Hueso

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