The enhancement of vincristine cytotoxicity by combination with feselol

Journal of Asian Natural Products Research
Samaneh MollazadehFatemeh Behnam-Rassouli

Abstract

Urinary bladder cancer is one of the most common cancers worldwide. Human transitional cell carcinoma (TCC) cells are epithelial-like adherent cells originally established from a primary bladder carcinoma. Studies have shown that TCC cells are resistant to some chemotherapeutic agents such as vincristine (VCR). In the present study, the effect of feselol, a sesquiterpene coumarin isolated from the fruits of Ferula badrakema, was investigated on VCR effectiveness. Our results demonstrated that feselol itself did not have any cytotoxic effect on TCC cells. In order to check its combinatorial effects, TCC cells were exposed to various combined concentrations of feselol and VCR. Then, morphological changes were monitored and cytotoxicity was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay for three consequent days. Results showed that the combination of 40 microg/ml VCR with 16 microg/ml feselol increased the cytotoxicity of VCR by 28.32% after 48 h. This effect might be due to inhibition of P-glycoprotein in TCC cells by feselol.

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Citations

Feb 15, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sara Soltanian, Maryam M Matin
Oct 13, 2011·Natural Product Research·Vajiheh NeshatiMorvarid Saeinasab
Oct 15, 2013·Drug and Chemical Toxicology·Azadeh HaghighitalabHassan Porsa
Mar 24, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Omid CheraghiSoheila Montazersaheb
Apr 5, 2011·Fitoterapia·Fatemeh Behnam RassouliAhmad Reza Bahrami
Dec 4, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Fatemeh Behnam RassouliFatemeh Kalalinia
Apr 11, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Maryam Moghaddam MatinFatemeh Behnam Rassouli

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