The enigma of microtubules and their self-organizing behavior in the cytoskeleton

Bio Systems
J A TuszyńskiM V Satarić

Abstract

The cytoskeleton of eukaryotic cells contains networks of protein polymers called microtubules which structurally and functionally organize their interiors. Both in vivo and in vitro microtubules exhibit a fascinating and yet poorly understood array of important functions involving complex self-organization phenomena which are very sensitive to physiological and laboratory conditions, respectively. In this paper we discuss the main physical characteristics of microtubules focusing our attention on four particular aspects: (a) the dynamics of their assembly and disassembly processes (b) the types and the range of existence of ordered dipolar phases and (c) modes of energy transfer and (d) information processing capabilities.

References

Jun 9, 1978·Science·L MargulisD Chase
Aug 1, 1992·The Journal of Cell Biology·S Kamimura, E Mandelkow
Jan 1, 1991·Journal of Cell Science. Supplement·S R HeidemannR E Buxbaum
Sep 1, 1991·The Journal of Cell Biology·E M MandelkowR A Milligan
Jan 1, 1991·Pharmacology, Biochemistry, and Behavior·G Bensimon, R Chermat
Dec 8, 1989·Science·E MandelkowS C Müller
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S S Matsuyama, L F Jarvik
Jan 1, 1986·Annals of the New York Academy of Sciences·S R HameroffR C Watt
Jan 1, 1974·Annals of the New York Academy of Sciences·H Athenstaedt
Jan 1, 1982·Cell and Tissue Research·H Stebbings, C Hunt
Oct 21, 1982·Journal of Theoretical Biology·S R Hameroff, R C Watt
Nov 15, 1984·Nature·J R McIntosh
Nov 15, 1984·Nature·T Mitchison, M Kirschner
Oct 29, 1981·Nature·R L Margolis, L Wilson
Apr 8, 1994·Science·B Hess, A Mikhailov
Jan 1, 1994·European Biophysics Journal : EBJ·A Marx, E Mandelkow
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y H Song, E Mandelkow
Mar 1, 1993·Molecular Biology of the Cell·B TrinczekE Mandelkow
Jul 1, 1993·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·M V SataricR B Zakula
Aug 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D K FygensonA Libchaber
Dec 1, 1992·Physical Review. B, Condensed Matter·M B Weissman, P G Wolynes
Jan 15, 1992·Physical Review. D·A K GuptaE W Kolb

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Citations

Dec 17, 2005·Bio Systems·Jean FaberLuiz Pinguelli Rosa
Aug 22, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·S HaganJ A Tuszyński
Nov 5, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Luiz Pinguelli Rosa, Jean Faber
Oct 24, 2006·Biophysical Journal·Piotr DrabikAndriy Kovalenko

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