The enigmatic function of chandelier cells

Frontiers in Neuroscience
Alan WoodruffRafael Yuste


Chandelier (or axo-axonic) cells are one of the most distinctive GABAergic interneurons in the brain. Their exquisite target specificity for the axon initial segment of pyramidal neurons, together with their GABAergic nature, long suggested the possibility that they provide the ultimate inhibitory control of pyramidal neuron output. Recent findings indicate that their function may be more complicated, and perhaps more interesting, than initially believed. Here we review these recent developments and their implications. We focus in particular on whether chandelier cells may provide a depolarizing, excitatory effect on pyramidal neuron output, in addition to a powerful inhibition.


Mar 27, 2012·Annual Review of Neuroscience·Kevin J Bender, Laurence O Trussell
Dec 27, 2011·The Journal of Physiology·Caren Armstrong, Ivan Soltesz
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Winnie WefelmeyerJuan Burrone
Dec 14, 2011·Trends in Neurosciences·David A LewisDavid W Volk
Jun 18, 2011·Current Opinion in Neurobiology·David A LewisGuillermo Gonzalez-Burgos
Oct 25, 2011·The Journal of Comparative Neurology·Xinjun Wang, Qian-Quan Sun
Jan 31, 2014·The Journal of Comparative Neurology·Anna N KingJames S Trimmer
Jan 28, 2015·Molecular Psychiatry·J A BrownKároly Mirnics
Feb 11, 2014·Trends in Neurosciences·Jennifer A Tyson, Stewart A Anderson
Feb 22, 2014·Current Opinion in Neurobiology·Melis Inan, Stewart A Anderson
Jan 31, 2012·Neuron·Maarten H P Kole, Greg J Stuart
Feb 12, 2013·Neuron·Corentin Le Magueresse, Hannah Monyer
May 21, 2016·Frontiers in Neural Circuits·Yiqing WangDaniel R Wyskiel
May 21, 2016·Frontiers in Neural Circuits·Alexander Naka, Hillel Adesnik
Sep 13, 2016·Frontiers in Computational Neuroscience·Christoph MetznerBartosz Zurowski
Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rinki SahaGal Richter-Levin
Feb 29, 2016·Cerebral Cortex·Ezzat HashemiVerónica Martínez-Cerdeño
Apr 25, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martin J Schmidt, Karoly Mirnics
Sep 20, 2017·Cerebral Cortex·Annabelle SchlüterMaren Engelhardt
Dec 13, 2012·Stroke; a Journal of Cerebral Circulation·Jason D HinmanS Thomas Carmichael
Sep 27, 2018·Journal of Neurophysiology·Helen BarbasMiguel Ángel García-Cabezas
May 18, 2011·The Journal of Biological Chemistry·Martin KriebelHansjürgen Volkmer
May 11, 2012·Developmental Neuroscience·Martin J Schmidt, Karoly Mirnics
Jul 13, 2019·Annual Review of Neuroscience·Gord Fishell, Adam Kepecs
Mar 12, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jerry L Chen, Elly Nedivi
Apr 20, 2019·Acta Physiologica·Branislav KrajcovicAles Stuchlik
Dec 5, 2020·Science·Anjali GourMoritz Helmstaedter
Jun 23, 2020·Trends in Neurosciences·Nicholas B GalloLinda Van Aelst
Jun 17, 2021·Nature Communications·Taylor H NewtonHenry Markram

❮ Previous
Next ❯

Methods Mentioned


Software Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.