The enigmatic role of H2Bub1 in cancer

FEBS Letters
Steven A Johnsen

Abstract

The post-translational modification of histone proteins plays an important role in controlling cell fate by directing essentially all DNA-associated nuclear processes. Misregulation and mutation of histone modifying enzymes is a hallmark of tumorigenesis. However, how these different epigenetic modifications lead to tumor initiation and/or progression remains poorly understood. Recent studies have uncovered a potential tumor suppressor role for histone H2B monoubiquitination (H2Bub1). Like many other histone modifications, H2Bub1 has diverse functions and plays roles both in transcriptional activation and repression as well as in controlling mRNA processing and directing DNA repair processes. Notably, H2Bub1 has been linked to transcriptional elongation and is preferentially found in the transcribed region of active genes. Its activity is intimately connected to active transcription and the transcriptional elongation regulatory protein cyclin-dependent kinase-9 (CDK9) and the facilitates chromatin transcription (FACT) complex. This review provides an overview of the current understanding of H2Bub1 function in mammalian systems with a particular emphasis on its role in cancer and potential options for exploiting this knowledge f...Continue Reading

References

Jan 19, 2000·Nature·B D Strahl, C D Allis
Aug 11, 2001·Science·T Jenuwein, C D Allis
Jul 18, 2002·The Journal of Biological Chemistry·Lih-Shen ChinLian Li
Sep 10, 2003·Journal of Medical Genetics·V M HowellB T Teh
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yuzuru Shiio, Robert N Eisenman
Oct 31, 2003·The New England Journal of Medicine·Trisha M ShattuckAndrew Arnold
Dec 9, 2003·The Journal of Biological Chemistry·Jeremy A DanielPatrick A Grant
Apr 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Branca M CavacoValeriano Leite
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Kathy A MasonLuka Milas
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Filomena CetaniClaudio Marcocci
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Sung-Dae MoonBong-Yun Cha
Jan 6, 2005·Molecular and Cellular Biology·Tiaojiang XiaoBrian D Strahl
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel E StangePeter Lichter
Feb 21, 2006·Clinical Endocrinology·K J BradleyR V Thakker
May 17, 2006·Genes & Development·Steven BerginkNico P Dantuma
Jun 15, 2006·Briefings in Functional Genomics & Proteomics·Mary Ann Osley
Aug 4, 2006·Molecular Cell·B Matija Peterlin, David H Price
Sep 26, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thomas G KellyThomas O Carpenter
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tao JiangPeter C Dedon
Nov 6, 2007·Current Biology : CB·Francesco NicassioElisabetta Citterio

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Citations

Aug 10, 2012·PLoS Genetics·Steven A Johnsen
Dec 7, 2013·World Journal of Gastroenterology : WJG·Zi-Jing WangLian-Di Guo
May 10, 2012·FEBS Letters·Wilhelm Just
Jan 26, 2013·Current Opinion in Cell Biology·Tanja Waldmann, Robert Schneider
Sep 9, 2015·Pathology Oncology Research : POR·Nathaniel MellingAndreas H Marx
Jan 15, 2014·Biochimica Et Biophysica Acta·Gilad Fuchs, Moshe Oren
Feb 25, 2014·Biochimica Et Biophysica Acta·Aristeidis G VaiopoulosAthanasios G Papavassiliou
May 20, 2014·Molecular Cell·Lipeng WuYali Dou
Jun 8, 2012·Cell Cycle·Magdalena E Morawska
Dec 3, 2014·Trends in Biochemical Sciences·Sheila S TevesSteven Henikoff
Apr 29, 2014·Cancer Letters·Jay Prakash SinghXiaoyong Yang
Sep 25, 2014·Frontiers in Endocrinology·Paweł JóźwiakAnna Krześlak
Jun 28, 2014·Frontiers in Oncology·Deborah J MarshAlexander J Cole
Jun 4, 2014·Endocrine-related Cancer·Alexander J ColeDeborah J Marsh
Oct 25, 2016·Biochimica Et Biophysica Acta·Ji ChengWenyi Wei
Nov 2, 2016·Nucleic Acids Research·Matthew R Northam, Kelly M Trujillo
May 10, 2017·International Journal of Molecular Sciences·Simon J Baumgart, Bernard Haendler
Jun 24, 2018·Bioscience Reports·Gautam SethiAlan Prem Kumar
Oct 16, 2018·Journal of Crohn's & Colitis·Robyn Laura KosinskySteven A Johnsen
Mar 16, 2018·Oncotarget·Muthu K ShanmugamManikandan Lakshmanan
Jul 4, 2019·Clinical Epigenetics·Deborah SchneiderRobyn Laura Kosinsky
Nov 1, 2016·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O A Buneeva, A E Medvedev
Jan 8, 2016·The Journal of Biological Chemistry·Stefanie BöhmKara A Bernstein
Apr 30, 2017·Transcription·Gregory Segala, Didier Picard
Apr 29, 2020·Cell Death & Disease·Wanhua XieSteven A Johnsen
Feb 18, 2017·Genome Biology·Wanhua XieSteven A Johnsen
Oct 3, 2015·Oncotarget·Robyn L KosinskySteven A Johnsen
Oct 19, 2020·Cell Death & Disease·Florian WegwitzSteven A Johnsen
Jan 7, 2021·International Journal of Molecular Sciences·Dominik Saul, Robyn Laura Kosinsky
Mar 10, 2021·Bulletin du cancer·Sa ZhouTongcun Zhang

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