The enteric nervous system promotes intestinal health by constraining microbiota composition

PLoS Biology
Annah S RoligKaren Guillemin

Abstract

Sustaining a balanced intestinal microbial community is critical for maintaining intestinal health and preventing chronic inflammation. The gut is a highly dynamic environment, subject to periodic waves of peristaltic activity. We hypothesized that this dynamic environment is a prerequisite for a balanced microbial community and that the enteric nervous system (ENS), a chief regulator of physiological processes within the gut, profoundly influences gut microbiota composition. We found that zebrafish lacking an ENS due to a mutation in the Hirschsprung disease gene, sox10, develop microbiota-dependent inflammation that is transmissible between hosts. Profiling microbial communities across a spectrum of inflammatory phenotypes revealed that increased levels of inflammation were linked to an overabundance of pro-inflammatory bacterial lineages and a lack of anti-inflammatory bacterial lineages. Moreover, either administering a representative anti-inflammatory strain or restoring ENS function corrected the pathology. Thus, we demonstrate that the ENS modulates gut microbiota community membership to maintain intestinal health.

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Related Concepts

Escherichia
Embryo
EDNRB
Neuro-Oncological Ventral Antigen 2
Real-Time Polymerase Chain Reaction
Sox10 protein, zebrafish
Biochemical Pathway
Fluorescent in Situ Hybridization
Immune System
Neutrophil Band Cells

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