The entropy cost of protein association

Journal of Molecular Biology
A Tamura, P L Privalov


The temperature induced unfolding/dissociation of the dimeric subtilisin inhibitor from Streptomyces and its mutant D83C having an S-S crosslink between the subunits has been studied calorimetrically. Comparison of the entropies measured at different concentrations of dimer showed that the entropy cost of crosslinking is small. Its value at the standard concentration of 1 M is of the order of -(5+/-4) cal/K.mol, i.e. it is more than one order of magnitude smaller than the values of translational entropies calculated on the base of statistical thermodynamics, using in particular the Sackur-Tetrode equation, and is close to the cratic entropy value suggested by classical mixing theory.


Apr 5, 1992·Journal of Molecular Biology·P L Privalov, G I Makhatadze
Jan 1, 1992·Protein Science : a Publication of the Protein Society·N Horton, M Lewis
Oct 1, 1989·Protein Engineering·A V Finkelstein, J Janin
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M I Page, W P Jencks
Jan 1, 1995·Proteins·J Janin
Jun 1, 1995·Biopolymers·A Holtzer
Apr 1, 1994·Protein Science : a Publication of the Protein Society·Y V GrikoR W Hartley
Aug 15, 1994·Archives of Biochemistry and Biophysics·J Myung, W P Jencks
Jun 1, 1993·Archives of Biochemistry and Biophysics·E Freire
Jan 1, 1995·Methods in Enzymology·E Freire
Jan 1, 1995·Advances in Protein Chemistry·G I Makhatadze, P L Privalov
Feb 1, 1997·Biophysical Journal·G P Brady, K A Sharp
Jan 1, 1959·Advances in Protein Chemistry·W KAUZMANN
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R Smith, C Tanford


Jul 21, 2001·Biophysical Journal·D Sept, J A McCammon
Jul 11, 2009·Chemical Reviews·Huan-Xiang Zhou, M K Gilson
Oct 27, 2011·Journal of the American Chemical Society·Bin W ZhangCharles L Brooks
Mar 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wei WangP G Wolynes
Dec 21, 2011·Protein Engineering, Design & Selection : PEDS·Nicholus Bhattacharjee, Parbati Biswas
Jul 20, 2006·The Journal of Chemical Physics·Arieh Ben-Naim
Sep 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jaime López de la OsaD V Laurents
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hengbin Luo, K A Sharp
Aug 7, 2008·Molecular Systems Biology·Jingshan ZhangEugene I Shakhnovich
May 23, 2017·The Journal of Physical Chemistry. B·Andrea Funke, Klaus Weisz
Oct 18, 2002·Advanced Drug Delivery Reviews·Y Bruce Yu
May 11, 1999·Protein Engineering·M Karplus, J Janin
Jan 6, 2004·Proteins·Xavier Siebert, L M Amzel
Aug 26, 2015·Nucleic Acids Research·Paulius VaitiekunasP L Privalov
Mar 30, 2001·The Journal of Biological Chemistry·R D BrokxG I Makhatadze
Mar 10, 2016·Physical Chemistry Chemical Physics : PCCP·Maxim P EvstigneevIgor V Golovchenko
Jan 19, 2018·Annual Review of Biophysics·A Joshua Wand, K A Sharp
Aug 25, 2004·Physical Review Letters·Erika BalogJeremy C Smith
Sep 2, 2004·Protein Science : a Publication of the Protein Society·Andrei L LomizeH I Mosberg
Jul 12, 2002·Proteins·Muhammad H ZamanTobin R Sosnick
Dec 26, 2002·Journal of Molecular Recognition : JMR·A V VeselovskyP Janssen
Apr 29, 2014·Journal of Computational Chemistry·Yutaka MaruyamaFumio Hirata
Mar 25, 2009·Cellular and Molecular Life Sciences : CMLS·Kaare TeilumBirthe B Kragelund
Jul 18, 2015·The Journal of Biological Chemistry·Trine Holst SørensenPeter Westh
Oct 1, 2008·Physical Biology·Jingshan Zhang, Eugene I Shakhnovich
Jul 28, 2016·European Biophysics Journal : EBJ·P L Privalov, C Crane-Robinson
Jan 18, 2006·The Journal of Biological Chemistry·Jorge P López-AlonsoD V Laurents
Sep 4, 2004·Journal of Receptor and Signal Transduction Research·Remo PerozzoLeonardo Scapozza
Mar 29, 2000·The Journal of Biological Chemistry·A LostaoJ Sancho
Feb 8, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Lev BrombergT Alan Hatton

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