The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci

Human Genetics
Patricia C ChuladaPerry J Blackshear

Abstract

The National Institute of Environmental Health Sciences is establishing a DNA repository named the Environmental Polymorphisms Registry (EPR). The goal is to recruit 20,000 subjects from the greater Research Triangle Park region of North Carolina and collect a sample of each subject's DNA for genetic study. Personal information is obtained from each EPR subject and linked to their sample in coded form. Once individuals with the genotypes of interest are identified, their samples are decoded, and their names and contact information are given to scientists for follow-up studies in which genotype is important. "Recruit-by-genotype" resources such as the EPR require a transparent consent process and rigorous human subjects protection measures. Unlike the EPR, most US DNA resources are anonymous. Once scientists identify potentially significant genetic variants, they must screen new populations to find individuals with the variants of interest to study. The EPR eliminates this time consuming and expensive step. In designing the EPR, consideration was given to achieving high response rates, minimizing attrition and maximizing usefulness for future research studies. Subjects are recruited from outpatient clinics in area medical center...Continue Reading

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May 25, 2012·Human Genetics·Laura M BeskowBenjamin S Wilfond
Sep 1, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Marsha MichieLaura M Beskow
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