The enzymatic activities and NBT reduction test of granulocytes in untreated and dialysed uraemic patients

Acta Haematologica
W SutowiczO Smoleński


It was found that neutrophils in untreated uraemic patients as well as in subjects on regular dialysis treatment displayed higher activity of acid phosphatase, alkaline phosphatase and peroxidase. Spontaneous reduction of nitro blue tetrazolium (NBT) by granulocytes was also higher in both groups in comparison to controls. Stimulation with latex particles gave similar results of NBT reduction in investigated patients and controls. Lymphocytes also showed an increase in acid phosphatase activity if compared to healthy persons. It seems possible that granulocytes which take part in unspecific defense mechanisms are more active in uraemic patients due perhaps to subclinical infections.


Feb 1, 1990·Kidney International·R A WardH J Gurland
Jul 1, 1993·Kidney International·R C VanholderS M Ringoir

Related Concepts

Acid Phosphatase
Alkaline Phosphatase
Kidney Failure, Chronic
Lymphoid Cells
Neutrophil Band Cells
Nitroblue Tetrazolium

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