PMID: 9188953Jan 1, 1997Paper

The eosinophil and the eye

Allergy
S BoniniS Bonini

Abstract

Personal studies in allergic eye diseases reviewed in this paper indicate that: 1. An increased number and an abnormal distribution of eosinophils is present in conjunctival biopsies of patients with vernal keratoconjunctivitis (VKC). 2. Eosinophil and eosinophil products, such as ECP, are also increased in tears of VKC patients and, in hay fever conjunctivitis, accumulate during the late-phase of allergic reaction following specific allergen challenge. 3. Circulating eosinophils of VKC patients show a typical activation phenotypic profile which is associated with increased serum level of eosinophil cationic protein and eosinophil-derived neurotoxin/protein X. A clinical study of the modulatory effect of cetirizine on the early and late phase of the allergic reaction as well as on the eosinophil activation and tissue recruitment following conjunctival allergen challenge is reported as an example of the need to evaluate eosinophil functions when investigating anti-allergic drugs. Drugs modulating various aspects of eosinophil function could play a primary role in the treatment of allergic eye disease.

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Citations

Jun 29, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Simone EperonYan Guex-Crosier
Jul 23, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Waka IshidaAtsuki Fukushima
Mar 15, 2002·Current Allergy and Asthma Reports·A Keane-Myers
Jun 5, 2002·Current Allergy and Asthma Reports·James L StahlFrank M Graziano
Dec 10, 2002·American Journal of Ophthalmology·Elisabeth M MessmerAnselm Kampik
Feb 6, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ellen B CookFrank M Graziano
Jan 25, 2003·International Ophthalmology Clinics·Stefano BoniniSergio Bonini
Jan 25, 2003·International Ophthalmology Clinics·Mitchell H Friedlaender
Jan 18, 2011·Respiratory Research·Jonas BystromDavid Bishop-Bailey
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J D MacLeod
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Mitchell H Friedlaender
Sep 7, 2004·Current Opinion in Allergy and Clinical Immunology·Mitchell H Friedlaender
May 17, 2007·International Archives of Allergy and Immunology·Atsuki FukushimaHisayuki Ueno
Jul 20, 2011·Archivos de la Sociedad Española de Oftalmología·R MartínezT Suárez
Aug 6, 2008·Biochemical Pharmacology·Ahmed R QasemSanti Spampinato
Jan 24, 2006·Progress in Retinal and Eye Research·Naoki KumagaiTeruo Nishida
May 22, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Atsuki FukushimaOsamu Taguchi
Oct 28, 2005·Current Eye Research·Murat DogruHiroshi Fujishima
Jul 19, 2018·Current Opinion in Allergy and Clinical Immunology·Arianna PrinceLeonard Bielory
Dec 21, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M DogruH Fujishima
Oct 6, 2006·Expert Opinion on Pharmacotherapy·César Picado
Jul 18, 2020·Current Opinion in Allergy and Clinical Immunology·Antonio Di ZazzoMerle Fernandes
Jan 1, 2014·Allergo Journal International·Soja ShamizadehJohannes Ring
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization

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