The epidemiology and prevention of invasive aspergillosis

The Journal of Hospital Infection
R J Manuel, C C Kibbler

Abstract

Over the past two decades, the incidence of invasive aspergillosis (IA) has risen inexorably. This is almost certainly the consequence of the more widespread use of aggressive cancer chemotherapy regimens, the expansion of organ transplant programmes and the advent of the acquired immunodeficiency syndrome (AIDS) epidemic. Despite the development of new approaches to therapy, IA still remains a life-threatening infection in immunocompromised patients and is the most important cause of fungal death in cancer patients. It is clear that the prevention of severe fungal infection by the use of effective infection control measure should be the priority of the teams involved in managing at-risk patients. The evidence from clinical and molecular epidemiological studies is reviewed and current thinking on sources and routes of transmission of the organism are discussed. Our increasing understanding of these has led to the development of a variety of environmental and general strategies for the prevention of IA. It is anticipated that these, coupled with the use of prophylactic antifungal agents active against Aspergillus spp., will have a significant impact upon the morbidity and mortality associated with this infection.

References

May 1, 1977·Annals of Internal Medicine·J AisnerS C Schimpff
Mar 7, 1992·Lancet·N K Eccles, G M Scott
Feb 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G BodeyS Milliken
Nov 1, 1992·Diagnostic Microbiology and Infectious Disease·M P PláE Bouza
Jan 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K J PursellD Armstrong
Jun 1, 1991·The Journal of Hospital Infection·F S Rhame
Jul 1, 1991·The Journal of Hospital Infection·H HumphreysD C Speller
Oct 1, 1991·The Journal of Antimicrobial Chemotherapy·D W Denning
Oct 6, 1990·Lancet·S VargasM A Giannini
Jun 1, 1991·The American Journal of Medicine·G M JefferyM I Schousboe
Jul 1, 1990·Archives of Environmental Health·K YoshidaK Uchida
Oct 6, 1990·BMJ : British Medical Journal·A G DewhurstJ R Dathan
Nov 1, 1990·Reviews of Infectious Diseases·D W Denning, D A Stevens
May 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G P Bodey, S Vartivarian
Aug 5, 1989·Lancet·R De BockN Nolard
Jul 1, 1989·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L L KlimowskiK M Cummings
Jun 1, 1989·European Journal of Epidemiology·T J Walsh, D M Dixon
Feb 1, 1988·The Journal of Hospital Infection·T R Rogers, R A Barnes
Jul 9, 1988·Lancet·M S WilkesW G Thompson
Jan 1, 1987·The British Journal of Surgery·R M KirbyD H Adams
Sep 1, 1988·Neuropathology and Applied Neurobiology·F GrayJ Poirier
Feb 1, 1987·Annals of Internal Medicine·J M HofflinJ S Remington
Dec 1, 1986·Journal of the Neurological Sciences·S RosembergA M Tsanaclis
Oct 1, 1985·Transplantation·C P WajszczukB Shaw
Oct 21, 1968·JAMA : the Journal of the American Medical Association·A M Saunders, C Bieber
Jan 1, 1973·The American Journal of Medicine·R D MeyerB Yu
Mar 1, 1970·Medicine·R C YoungV T DeVita
Oct 1, 1971·Archives of Internal Medicine·M J GurwithJ S Remington
Sep 1, 1968·Thorax·A H Henderson
May 15, 1984·The American Journal of Medicine·F S RhameP B McGlave
May 1, 1984·Southern Medical Journal·M C Zarabi, S Salmassi

❮ Previous
Next ❯

Citations

Mar 20, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·UNKNOWN Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (RKI)
Mar 10, 2010·Archives of Environmental Contamination and Toxicology·Vivechana DixitS Kay Obendorf
Sep 1, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Arne SimonGudrun Fleischhack
Apr 20, 2010·General Thoracic and Cardiovascular Surgery·Hideki TeshimaShigeaki Aoyagi
Feb 7, 2003·Journal of the American College of Cardiology·Angel Sanchez-RecaldeJosé A Sobrino
Jun 26, 2001·Journal of Clinical Pharmacy and Therapeutics·L WillemsK de Beule
Nov 8, 2002·Mycoses·H SridharB R VijayKumar
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J DasbachS M Teutsch
Jul 13, 2002·The American Journal of Nursing·C Morrison, E Lew
Apr 28, 2001·Journal of Clinical Microbiology·S BertoutUNKNOWN European Research Group on Biotype and Genotype of Aspergillus
Jan 7, 2005·Journal of Clinical Microbiology·Maria José LinaresM Casal
May 5, 2012·Revista iberoamericana de micología·Rafael Tormo-MolinaInmaculada Silva-Palacios
Aug 30, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P MuñozE Bouza
Sep 20, 2015·Journal of Medical Microbiology·Fereshteh ZareiJamal Hashemi
Jun 13, 2006·American Journal of Infection Control·Fernanda PerdelliMaria Luisa Cristina
Apr 8, 2003·Journal of Chemotherapy·G DimopoulosJ L Vincent
Aug 30, 2001·Critical Care Clinics·A Safdar, D Armstrong
Aug 27, 2013·International Journal of Food Microbiology·Doris HaasWalter Buzina
Feb 9, 2000·The Journal of Hospital Infection·G MorrisM D Richardson
Nov 20, 2009·American Journal of Infection Control·Isabelle FournelLudwid-Serge Aho-Glélé
Nov 2, 2016·The Journal of Infectious Diseases·Shane R BaistrocchiDonald C Sheppard
Mar 1, 2002·British Journal of Nursing : BJN·E JohnsonM Stephens
Oct 13, 2006·Current Opinion in Infectious Diseases·C C Kibbler, H G Prentice
Jun 15, 2006·Journal of Medical Microbiology·D A EnochN M Brown
Oct 7, 2005·Expert Review of Anti-infective Therapy·Livio PaganoLuana Fianchi
Sep 12, 2000·The Annals of Pharmacotherapy·J A Sabo, S M Abdel-Rahman
Mar 5, 2004·Hospital Medicine·Mark H Wilcox

Jan 5, 2021·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.