The epidemiology, clinical characteristics, histopathology and management of juvenile- and adult-onset corneoscleral limbus xanthogranuloma

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Georgios T KontosSarah E Coupland

Abstract

Adult-onset xanthogranuloma (AOX) of the corneoscleral limbus is a rare inflammatory condition of unknown aetiology. Similar to limbal juvenile xanthogranuloma (JXG), it presents as a growing mass at the corneoscleral junction. Limbal AOX and JXG can lead to sight-threatening complications if not managed in a timely manner. This systematic review summarises the main clinical and histopathological features of limbal AOX/JXG and discusses the management of this uncommon disease. We performed a literature search in the MEDLINE database for all historical entries, using the search terms "limbus", "limbal" and "xanthogranuloma", and retrieved all articles reporting on limbal xanthogranuloma. After refining the search to articles relevant to limbal AOX, we were able to identify ten adult cases of limbal AOX and compare those with all reported cases of limbal JXG. Clinically, AOX usually presents as an isolated smooth, yellowish, dome-shaped nodule at the corneoscleral junction, similar to an ocular presentation of JXG, with which it also shares similar histopathological features. Limbal JXG and AOX may represent the same disease entity. Diagnosis relies on the clinical presentation, pathology and immunohistochemical profile. Spontane...Continue Reading

References

Jun 15, 1991·American Journal of Ophthalmology·P H KalinaH Buettner
Oct 1, 1974·American Journal of Ophthalmology·F A Jakobiec
Mar 1, 1983·Archives of Ophthalmology·O Litriĉin
May 1, 1984·The British Journal of Ophthalmology·L M Collum, J Mullaney
May 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J Fischbach, W Sause
Jul 1, 1995·Archives of Ophthalmology·M Yanoff, H D Perry
Aug 1, 1994·The British Journal of Ophthalmology·P HarveyJ R Goepel
Mar 26, 1998·Archives of Ophthalmology·V C ParmleyL A Fannin
Sep 8, 2001·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·J J WangE Tu
Jan 25, 2002·Archives of Ophthalmology·Akira KobayashiAndrew J W Huang
Sep 15, 2004·American Journal of Ophthalmology·Tishu SaxenaRadhika Tandon
Nov 9, 2004·Survey of Ophthalmology·Imtiaz A ChaudhryFenwick Riley
Jul 15, 2005·Cornea·Zena Lim-I-Linn, Lim Li
Jul 31, 2007·Japanese Journal of Ophthalmology·Tomo NishiYoshiaki Hara
Jul 31, 2007·Japanese Journal of Ophthalmology·Megumi HirataYuichiro Ogura
Nov 7, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gita RamjeeUNKNOWN HPTN 055 Study Team
Jan 12, 2008·Indian Journal of Dermatology, Venereology and Leprology·Surajit NayakManoj Kumar Patra
Nov 13, 2009·Cornea·Martin HermelAndreas Remky
Dec 23, 2010·Ophthalmic Genetics·Christophe De KeyserIngele Casteels
Jun 23, 2011·Clinical Medicine Insights. Oncology·Rong Fan, Jihong Sun
Dec 14, 2011·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Susannah LongmuirSandy Hong
Nov 26, 2013·Archivos de la Sociedad Española de Oftalmología·M Castro-GómezE Vergara Alcaide
Jun 11, 2014·Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi·Henry H W LauDorothy S P Fan
Jun 17, 2014·Acta Ophthalmologica·Georgios T KontosSay Aun Quah

❮ Previous
Next ❯

Citations

Mar 1, 2019·European Journal of Ophthalmology·Osama M Mustafa, Yassine J Daoud
Oct 29, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M ZimmermannA Gericke
Sep 24, 2019·Veterinary Ophthalmology·Alexandra M HarveyRichard R Dubielzig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Related Papers

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Zi-qin LiuJi-zhen Zou
Archives of Ophthalmology
Akira KobayashiAndrew J W Huang
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
J J WangE Tu
© 2022 Meta ULC. All rights reserved