The epidemiology of central fat distribution in relation to disease

Nutrition Reviews
F Xavier Pi-Sunyer

Abstract

The effect of fat distribution on disease risk is a subject of great interest. Central fat has been measured anthropometrically, by computed tomography, and by magnetic resonance imaging. Both cross-sectional and longitudinal studies have related central fat to type 2 diabetes mellitus and cardiovascular disease, independent of body mass index. The mechanism may relate to increased lipolysis causing the liver to increase glucose and very low density lipoprotein output, while muscle uses less. This leads to a rise in blood glucose and triglycerides, a drop in HDL cholesterol, and an increase in small, dense LDL particles. There is also an increase in blood pressure and inflammatory markers. Certain populations put on excess fat more centrally than others. These include Asian populations. It is likely that with better differentiation of abdominal fat into visceral and subcutaneous depots, clearer data will accrue on their impact on disease risk.

References

Feb 1, 1992·Journal of Applied Physiology·R RossR Guardo
Oct 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·K M ShelgikarC S Yajnik
Sep 1, 1991·The American Journal of Clinical Nutrition·J P DesprésC Bouchard
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C J ThompsonJ R Crouse
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Oct 1, 1990·Metabolism: Clinical and Experimental·M Rebuffé-ScriveP Björntorp
Jun 1, 1989·Annals of Internal Medicine·A N PeirisA H Kissebah
Aug 1, 1989·The American Journal of Clinical Nutrition·J C SeidellG Doornbos
Apr 11, 1987·Lancet·R P DonahueK Yano
May 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·M EmaraF F Fenech
Dec 1, 1987·The American Journal of Clinical Nutrition·D J ScholfieldK R Revett
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A J AndersonH W Gruchow
Feb 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P S SharpE M Kohner
Jul 1, 1985·Hypertension·R L WeinsierT B Van Itallie
Sep 1, 1983·The Journal of Clinical Investigation·M KrotkiewskiU Smith
Jan 1, 1984·Metabolism: Clinical and Experimental·D J EvansA H Kissebah
Jan 1, 1984·American Journal of Epidemiology·A J HartzA A Rimm
Feb 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A H KissebahP W Adams
Feb 1, 1981·American Journal of Epidemiology·W C KnowlerP H Bennett
Apr 1, 1995·The American Journal of Clinical Nutrition·J M ConwayV S Hubbard
Oct 1, 1993·Annals of Internal Medicine·F X Pi-Sunyer
Oct 1, 1993·The American Journal of Clinical Nutrition·S LemieuxJ P Després
Sep 1, 1995·Obesity Research·Y MatsuzawaK Tokunaga

❮ Previous
Next ❯

Citations

Mar 16, 2011·American Journal of Perinatology·Amy ShahAaron B Caughey
Jun 2, 2012·Biology of Sex Differences·Kalypso KarastergiouSusan K Fried
Nov 10, 2006·The British Journal of Nutrition·Su-Mei XiaoHong-Wen Deng
Oct 1, 2011·Obesity Research & Clinical Practice·Tetsuji ShinoharaHironobu Yoshimatsu
Dec 3, 2008·Clinical Cornerstone·Sydney A Westphal
May 24, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Helen Millar
Jun 30, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Claudio L LafortunaAlessandro Sartorio
May 1, 2007·Diabetes Research and Clinical Practice·Alessandro SartorioClaudio L Lafortuna
Jun 15, 2007·Archives of Medical Research·Gerson PeltzMary Kay Fadden
Nov 23, 2007·Journal of Gastroenterology and Hepatology·Pi-Jung HsiaoMing-Lung Yu
Mar 15, 2008·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·D K HoustonS B Kritchevsky
Oct 27, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Julienne N RutherfordChristopherw Kuzawa
May 12, 2010·International Journal of Clinical Practice·D Taner ErtugrulE Tutal
Jan 16, 2015·Computers in Biology and Medicine·Bum Ju Lee, Jong Yeol Kim
Sep 3, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Carlo CervellatiCarlo M Bergamini
Apr 7, 2005·Current Medical Research and Opinion·T D FilippatosM S Elisaf
May 25, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Katsuyasu KoudaHideo Yoneshima
Oct 23, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Taulant MukaJessica C Kiefte-de Jong
Jan 8, 2017·Annual Review of Pharmacology and Toxicology·Georgios ValsamakisGeorge Mastorakos
May 11, 2017·American Journal of Human Biology : the Official Journal of the Human Biology Council·Christiane Scheffler, Melanie Dammhahn
Aug 1, 2018·Expert Review of Endocrinology & Metabolism·Salar FarahvarEyal Sheiner
Oct 25, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S A JebbA M Prentice
Jan 19, 2008·Journal of Applied Physiology·Shin-Da LeeChih-Yang Huang
Nov 22, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Heidi S LumishMuredach P Reilly
Jun 12, 2019·Stress : the International Journal on the Biology of Stress·Angela Y ChiehLi Li
May 21, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Anne H Y ChuShiao-Yng Chan
Jan 12, 2017·Bioscience Reports·Sara L PulitCecilia M Lindgren
Jan 16, 2007·Cancer Causes & Control : CCC·Ute NöthlingsLaurence N Kolonel
Oct 27, 2011·Journal of Strength and Conditioning Research·Michael J Ormsbee, Paul J Arciero
Nov 14, 2013·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jihye BaekJaehoon Roh
Feb 7, 2014·BMC Cardiovascular Disorders·Fei-Shih YangRicardo C Cury
Dec 30, 2014·International Journal of Epidemiology·Golareh AghaEric B Loucks
Jun 24, 2005·American Journal of Epidemiology·Valentina ParacchiniEmanuela Taioli

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.