PMID: 8597464Dec 29, 1995Paper

The epidemiology of DHEAS and cardiovascular disease

Annals of the New York Academy of Sciences
E L Barrett-Connor, D Goodman-Gruen

Abstract

In 1986 we reported that high levels of plasma dehydroepiandrosterone sulfate (DHEAS) reduced the risk of fatal cardiovascular disease (CVD) in 242 men and increased the risk in 289 women from the Rancho Bernardo cohort who were followed up for 12 years. We report here an update on the epidemiology of DHEAS and CVD based on a 19-year follow-up of 1,029 men and 942 women aged 30-88 years from the same cohort. In cross-sectional analyses, DHEAS levels decreased with age in both sexes and were lower in women than men. Men who were overweight were more likely to have low DHEAS levels; women who had hypercholesterolemia or hypertension or were nonusers of estrogen therapy had higher DHEAS levels. Alcohol intake and cigarette smoking were associated with higher DHEAS levels in both sexes. All differences were no longer statistically significant after adjusting for alcohol intake. All participants were followed for vital status. After 19 years there were 254 CVD deaths in men and 199 CVD deaths in women. DHEAS was not associated with CVD or ischemic heart disease (IHD) deaths in age-adjusted analyses where the comparison group was individuals without CVD or IHD death. In contrast, when the comparison group was survivors, multiply adju...Continue Reading

References

Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·B R Hopper, S S Yen
Nov 15, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·M R SmithP V Bertrand
Apr 1, 1990·Journal of the American Geriatrics Society·D RudmanD E Mattson
Nov 1, 1990·Journal of the American College of Cardiology·D M HerringtonT A Pearson
Dec 11, 1986·The New England Journal of Medicine·E Barrett-ConnorS S Yen
Feb 1, 1969·The Journal of Clinical Endocrinology and Metabolism·T Yamaji, H Ibayashi
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·N OrentreichJ H Vogelman
Dec 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·A HautanenH Adlercreutz
Oct 1, 1959·Angiology·E KASK

❮ Previous
Next ❯

Citations

Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·S LegrainE E Baulieu
Nov 1, 2000·The Prostate. Supplement·A W van den Beld, S W Lamberts
Jun 6, 2003·Endocrine Reviews·Peter Y LiuDavid J Handelsman
Mar 24, 2005·Treatments in Endocrinology·Deborah R Cameron, Glenn D Braunstein
May 20, 2005·Endocrine Reviews·Jean M Kaufman, Alex Vermeulen
Oct 16, 2009·Climacteric : the Journal of the International Menopause Society·A R Genazzani, N Pluchino
Jan 1, 2006·Expert Review of Endocrinology & Metabolism·Melanie J Walton, Richard A A Anderson
Jun 4, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Qi QiuYang Lin
Nov 15, 1997·Journal of the American Geriatrics Society·R A Miller
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Mark A YorekJoseph S Dillon
Jul 20, 2002·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Brian Corrigan
May 13, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Noriyuki HommaMasahiko Oka
Sep 9, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anne R CappolaLinda P Fried
Oct 16, 2010·Psychosomatic Medicine·Michael C GadingerJoachim E Fischer
Dec 9, 2008·Acta Pharmacologica Sinica·Heng-hui ChengQiu-rong Ruan
Apr 25, 2012·Rejuvenation Research·Paola FortiMarco Zoli
Sep 10, 2013·Pulmonary Circulation·Eric D AustinMasahiko Oka
Jun 28, 2013·British Journal of Pharmacology·K M MairM R MacLean
Aug 22, 2020·Clinical Interventions in Aging·Ahmad H Alghadir, Sami A Gabr
Jul 7, 2001·American Journal of Therapeutics·R J Gaytan, L M Prisant
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·W PengI S Farrukh
Apr 18, 2003·Endocrine Reviews·Fredrick C W Wu, Arnold von Eckardstein
Sep 15, 2005·American Journal of Physiology. Endocrinology and Metabolism·Hidetaka HougakuE Jeffrey Metter
Dec 29, 1999·Medicine and Science in Sports and Exercise·M B WallaceL Bucci
May 20, 1999·Pharmacotherapy·M WellmanJ P Jennings
Aug 24, 2005·Journal of Cardiovascular Pharmacology·Stuart J HutchisonKrishnankutty Sudhir
Jun 19, 2007·Endocrinology·Tommaso Simoncini, Andrea R Genazzani
Feb 23, 2019·Frontiers in Endocrinology·Andreas YiallourisElizabeth O Johnson
Jul 28, 2019·Clinical and Experimental Pharmacology & Physiology·Ting-Ting WuXiang Xie
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J R RouleauJ G Kingma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.