The Epidemiology of Herpes Simplex Virus Type 1 in Asia: Systematic Review, Meta-analyses, and Meta-regressions

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Lara KhadrLaith J Abu-Raddad

Abstract

Herpes simplex virus type 1 (HSV-1) epidemiology in Asia was characterized by assessing seroprevalence levels and extent to which HSV-1 is isolated from clinically diagnosed genital ulcer disease (GUD) and genital herpes. HSV-1 reports in Asia were systematically reviewed and synthesized, following PRISMA guidelines. Random-effects meta-analyses estimated pooled mean seroprevalence and proportion of HSV-1 detection in GUD and genital herpes. Random-effects meta-regressions identified predictors of seroprevalence and sources of between-study heterogeneity. Forty-nine relevant publications were identified. Fifty-four overall seroprevalence measures (182 stratified measures), and 8 and 24 proportions of HSV-1 detection in GUD and in genital herpes, respectively, were extracted. The pooled mean seroprevalence was 50.0% (n = 26; 95% confidence interval [CI], 41.3%-58.7%) for children and 76.5% (n = 151; 73.3%-79.6%) for adults. By age group, the pooled mean was lowest at 55.5% (n = 37; 95% CI, 47.5%-63.4%) in individuals aged <20 years, followed by 67.9% (n = 48; 62.4%-73.3%) in those aged 20-39 and 87.5% (n = 44; 83.4%-91.1%) in those aged ≥40 years. In meta-regression, age was the major predictor of seroprevalence. The mean propor...Continue Reading

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Citations

Jun 10, 2020·Bulletin of the World Health Organization·Charlotte JamesKatharine J Looker
Jul 18, 2020·BMJ Global Health·Wajiha YousufLaith Abu-Raddad
Jul 3, 2020·European Archives of Psychiatry and Clinical Neuroscience·Seongman BaeSung-Han Kim
Jun 22, 2020·Enfermedades infecciosas y microbiología clínica·Mikele Macho-AizpuruaRamon Cisterna-Cancér
Aug 2, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tekumalla SindhujaSomesh Gupta
Sep 26, 2021·Journal of Paediatrics and Child Health·Angela BerkhoutClare Nourse
Oct 9, 2021·Ophthalmic Epidemiology·Ian McCormickKatharine J Looker

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
Assay
ELISA
nucleic acid amplification

Software Mentioned

metareg
meta
/ SE
R
Endnote
Stata
PRISMA

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