The epidemiology of hospitalised acute kidney injury not requiring dialysis in England from 1998 to 2013: retrospective analysis of hospital episode statistics

International Journal of Clinical Practice
Nitin V KolheMaarten W Taal

Abstract

Epidemiology studies of acute kidney injury (AKI) have focused on cases requiring dialysis but those not requiring dialysis represent the majority. To address this gap, we interrogated hospital episode statistics (HES) to investigate population trends in temporal epidemiology of AKI not requiring dialysis between 1998 and 2013. In this retrospective observational study of HES data covering the entire English National Health Service, we identified 1,136,167 AKI events, not requiring dialysis, diagnosed between 1998 and 2013. We explored the effect of age, gender, ethnicity, Charlson's comorbidity score (CCS), method of admission, diagnosis period and AKI in diagnosis codes on temporal changes in the incidence and case-fatality of AKI with specific examination of its predictors. The incidence of AKI increased from 15,463 cases (317 pmp) in 1998-1999 to 213,700 cases (3995 pmp) in 2012-2013. There was increase in proportion of people over 75 years from 51.1% in 1998-1999 to 63.4% in 2012-2013. Overall unadjusted case-fatality decreased from 42.3% in 1998-2003 to 27.1% in 2008-2013, p < 0.001. Compared with 1998-2003, the multivariable adjusted odds ratio for death was 0.64 in 2003-2008 (95% CI 0.63-0.65) and 0.35 in 2008-2013 (95%...Continue Reading

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Citations

Mar 31, 2016·International Journal of Clinical Practice·D Goldsmith
Aug 31, 2016·Nature Reviews. Nephrology·Joerg C SchefoldStephan von Haehling
Aug 24, 2018·Anesthesia and Analgesia·Alexander ZarbockJohn A Kellum
Oct 17, 2018·International Journal of Clinical Practice·Leslie Citrome
May 10, 2018·Journal of Intensive Care Medicine·Nithin Karakala, Ashita J Tolwani
Jul 27, 2017·BioMed Research International·Sasa NieXiangmei Chen
Jun 10, 2018·BMC Nephrology·Joel NeugartenNitin V Kolhe
Aug 24, 2018·Nature Reviews. Nephrology·Eric A J HosteLakhmir S Chawla
Nov 14, 2020·Anesthesia and Analgesia·Catharina Conrad, Holger K Eltzschig

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