The epidemiology of lost residual beta-cell function in short term diabetic children

Acta paediatrica Scandinavica
G DahlquistS Wall


Using the country-wide Swedish childhood diabetes register 526 children, who had had diabetes for 6-30 months were traced for measurements of 24-hour urinary C-peptide. Lost beta-cell function was defined as a 24-hour urinary C-peptide excretion per kg body weight less than 10% of the mean for healthy children (less than 0.025 nmol/kg). The estimated cumulative incidence of lost beta-cell function was 0.64 at 30 months. The incidence of lost beta-cell function did not differ by sex. Neither was there any significant variation in season at onset for cases with lost beta-cell function. A significant age dependency was shown for the cumulative incidence of lost beta-cell function with the highest incidence in the young age groups, i.e. a reversed age dependency compared to that of clinical onset. In contrast to the clinical onset of diabetes no significant geographical variation was found for lost beta-cell function when comparing standardized morbidity ratios. The urinary C-peptide excretion was significantly correlated to age at onset but not to degree or duration of ketonuria at onset. It is concluded that there are striking differences when comparing the epidemiology of lost beta-cell function to that of clinical onset in term...Continue Reading


Jul 10, 2008·Diabetes/metabolism Research and Reviews·Maria Nordwall, J Ludvigsson
Jan 9, 2010·La Radiologia medica·G CompagnoneG Califano
Jan 1, 1989·American Journal of Industrial Medicine·L JärupS Wall


Jan 1, 1978·Diabetes·J Ludvigsson, L G Heding
Jul 1, 1979·Acta paediatrica Scandinavica·E HeinzeE Kleihauer
Dec 1, 1976·Diabetologia·J Ludvigsson, L G Heding
Jul 24, 1986·The New England Journal of Medicine·S A AmielW V Tamborlane
Jan 1, 1987·Acta paediatrica Scandinavica·M WallensteenG Dahlquist
Mar 1, 1985·Archives of Disease in Childhood·S Rogers, M Silink
Nov 1, 1971·Clinical Science·M FahlénG Tibblin
Sep 1, 1983·Annals of Internal Medicine·S SrikantaG S Eisenbarth
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·H Yki-Järvinen, V A Koivisto
Nov 1, 1982·Acta paediatrica Scandinavica·M KnipH K Akerblom
Apr 1, 1982·Diabetologia·L Suarez, E Barrett-Connor
Mar 1, 1980·The Journal of Pediatrics·M MenchiniG Chiumello
Jan 1, 1981·Pediatric Research·J R CrossleyB W Edgar
Mar 1, 1982·The Journal of Clinical Endocrinology and Metabolism·P M BlixA H Rubenstein

Related Concepts

Seasonal Variation
Insulin B Chain
Diabetes, Autoimmune
Hb A1a-2
Age Factors
Islets of Langerhans

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.