The epidemiology of Lp-PLA(2): distribution and correlation with cardiovascular risk factors in a population-based cohort

Atherosclerosis
Margaretha PerssonG Berglund

Abstract

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that is produced by inflammatory cells (macrophages, T-lymphocytes and mast cells) and hydrolyzes oxidized phospholipids in LDL. Several epidemiology studies indicate that Lp-PLA(2) appears to be an independent marker of cardiovascular risk. This study was conducted to define the distribution of Lp-PLA(2) in a large population-based cohort and to determine associations between Lp-PLA(2) and other risk factors for CVD. The study group consisted of participants from the Malmö Diet and Cancer study (1992-1994). Lp-PLA(2) (activity and mass) was measured from samples obtained at baseline for 5402 participants (3167 women). A strong correlation was observed between Lp-PLA(2) activity and mass in this study (r=0.57). Highest correlations were observed between Lp-PLA(2) activity and LDL (r=0.45) and LDL/HDL ratio (r=0.54) and a strong inverse correlation to HDL (r=-0.31). The correlations between Lp-PLA(2) mass and lipids were not as strong as the correlation between activity and lipids. Lp-PLA(2) activity and mass were correlated with increased ultrasound determined carotid intima-media thickness. We conclude that Lp-PLA(2) is strongly correlated with several cardiova...Continue Reading

References

Jan 1, 1978·Journal of Chronic Diseases·H L TaylorG Debacker
Jul 18, 1997·The Journal of Biological Chemistry·D M StafforiniS M Prescott
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Mertens, P Holvoet
May 25, 2002·Scandinavian Journal of Public Health·Jonas ManjerGöran Berglund
Jun 19, 2002·Trends in Cardiovascular Medicine·Burkhard LudewigHans Hengartner
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson

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Citations

Nov 26, 2008·European Journal of Nutrition·Maria Weinkouff PedersenErik Berg Schmidt
Aug 27, 2011·Current Atherosclerosis Reports·Cheuk-Kit Wong, Harvey D White
Mar 5, 2013·Current Treatment Options in Cardiovascular Medicine·Koto Ishida, Brett Cucchiara
Oct 1, 2011·Lipids in Health and Disease·Isis T SilvaNágila R T Damasceno
May 6, 2010·PLoS Genetics·Sunil SuchindranJeanette J McCarthy
Sep 15, 2015·Clinical Biochemistry·Leslie J DonatoAllan S Jaffe
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
Nov 9, 2010·Journal of Internal Medicine·K C Epps, R L Wilensky
Sep 11, 2012·European Journal of Clinical Investigation·Alexander ConstantinidesRobin P F Dullaart
Feb 22, 2012·Journal of the American College of Cardiology·Jane F FergusonMuredach P Reilly
Jun 16, 2007·Biochimica Et Biophysica Acta·Gilbert O FruhwirthAlbin Hermetter
Nov 4, 2017·Medical Sciences : Open Access Journal·Lamiaa A A BarakatEl-Sayed Abd El-Sameeh El-Sayed
Jan 4, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Michael John PeckRolf Weitkunat
Nov 26, 2010·Circulation·Philip GreenlandUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Oct 20, 2010·Hemodialysis International·Aparna R BitlaSrinivasa Rao Pemmaraju Venkata Lakshmi Narasimha

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