The epidemiology of multiple myeloma

Seminars in Hematology
B G Durie

Abstract

Increases in the incidence of multiple myeloma during this past century implicate environmental factors as important causal agents. The molecular and cytogenetic alterations in multiple myeloma are under investigation, but the precise causes of these abnormalities are largely unknown. Exposure to chemical substances and ionizing radiation are associated with an increased risk of multiple myeloma. A single insult is probably not sufficient to induce the disease, which results from the clonal expansion of an idiotypic plasma cell after cumulative mutational damage has altered its genetic makeup. Multiple myeloma does not have the same biology in all patients; it is best viewed as a heterogeneous disease with a different prognosis, clinical course, and response to therapeutic interventions in different subjects. Full details of the genetic background in a given patient are required to better understand the disease. Hopefully this information will be available soon, using DNA array and related technologies.

Citations

Apr 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Françoise Pontet
Feb 2, 2011·AORN Journal·Lois Hamlin, Leigh Anderson
Jul 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marianne WeiresKari Hemminki
Mar 27, 2010·Social Science & Medicine·Glenis Tabetha Mark, Antonia C Lyons
Jul 7, 2009·Lancet·Malcolm KingMichael Gracey
Aug 21, 2004·International Journal of Mental Health Nursing·Anthony P O'BrienAnthony J O'Brien
Sep 16, 2008·International Journal of Mental Health Nursing·Nick Drury, Te Ata Munro
Jun 13, 2006·Nursing & Health Sciences·Antoinette M McCallin
Sep 22, 2010·Journal of Paediatrics and Child Health·Catherine A Byrnes, Adrian Trenholme
May 31, 2012·Journal of Clinical Nursing·Denise Wilson, Pipi Barton
Dec 18, 2013·Health & Social Care in the Community·Rosemary FreyMerryn Gott
Apr 12, 2005·La Revue de médecine interne·S LadoireP Pfitzenmeyer
Jul 1, 2015·Australian and New Zealand Journal of Public Health·Carol WhamNgaire Kerse
Sep 10, 2004·Clinical Journal of Oncology Nursing·Brent Devenney, Christy Erickson
May 14, 2011·The Australian and New Zealand Journal of Psychiatry·Deanna SandersElizabeth Broadbent
Aug 21, 2007·The International Journal of Social Psychiatry·Rees Tapsell, Graham Mellsop
Jul 23, 2014·Explore : the Journal of Science and Healing·Glenis Mark, Antonia Lyons
Aug 4, 2005·Journal of Child Health Care : for Professionals Working with Children in the Hospital and Community·Susan E Gasquoine
Jul 28, 2005·Nursing Ethics·Pauline WarehamKate Diesfeld
Feb 26, 2011·Clinical Child Psychology and Psychiatry·Eva CadarioSally Nicola Merry
Oct 3, 2014·Qualitative Health Research·Rhonda M Shaw, Robert Webb
Jul 21, 2012·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Allister Bush, Wiremu Niania
Jul 23, 2003·The Australian and New Zealand Journal of Psychiatry·Melanie AbasPeter Crampton
Aug 10, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·S AbelK J Coppell
Oct 6, 2018·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Leigh Duncan
Nov 15, 2018·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Diana M Kopua
Nov 5, 2005·Oncology Nursing Forum·Joseph D Tariman, Stella Marie Estrella
Jun 16, 2015·Palliative & Supportive Care·Wendy DugglebyThane Chambers
May 23, 2014·Palliative & Supportive Care·Jennifer Angelo, Richard Egan
Mar 16, 2012·The International Journal of Pharmacy Practice·Debbie Bassett-ClarkeBeata Bajorek
Aug 14, 2002·Pharmacotherapy·Rita M Cool, Jon D Herrington
Nov 14, 2006·Journal of Occupational and Environmental Medicine·Grace K LeMastersJames Lockey

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