The epidermal helix: a model for the bilayer couple phenomenon

Archives of Dermatological Research
W B Shelley, L Juhlin

Abstract

Narrow strips of isolated epidermis rapidly assume a helical conformation when placed in a dilute hypotonic aqueous solution of histamine as a free base. The same belical formations could be induced by dilute hypotonic solutions of alkalis or acids. This coiling resulted from damage to the malpighian cells, with consequent asymmetric osmotic swelling of the epidermis, thus producing torsional forces on the stratum corneum. In essence, the epidermal helix proved to be a pH dependent, osmotically induced, bilayer couple phenomenon.

References

Dec 10, 2009·The Journal of Experimental Medicine·Akiharu KuboMasayuki Amagai
Nov 13, 2004·Skinmed·Oumeish Youssef Oumeish

Citations

Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M P Sheetz, S J Singer

Related Concepts

Histamine Measurement
Paraparesis
Molecular Helix
Helix (Snails)
Hypercalcemia
Kinematics
Allergy Testing Histamine (Lab Test)
Acids
Histamine
Hypotonicity

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