The epigenetic basis of the Warburg effect

Epigenetics : Official Journal of the DNA Methylation Society
X Wang, Hongchuan Jin

Abstract

Cancer development results from the accumulation of genetic and epigenetic changes. By interacting with intracellular signaling to promote carcinogenesis, epigenetic networks can actively transform cancer-promoting signals from tumor-permissive microenvironment to coordinate cellular proliferation and metabolism in the initiation and progression of cancers. As reported recently, NF-kappaB which can be activated by many soluble bioactive factors enriched in tumor microenvironments can promote the switch of cellular glucose metabolism from oxidative phosphorylation to oxygen-independent glycolysis in tumor cells, in addition to its well-known anti-apoptosis functions. Such epigenetic trans-generation of microenvironmental factors plays important roles in the development of cancers, particularly inflammation-related or sporadic cancers.

Citations

Feb 23, 2013·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Viktor Shtilbans
May 31, 2013·Journal of Human Genetics·Shinjiro HinoMitsuyoshi Nakao
Apr 14, 2012·Nature Reviews. Drug Discovery·Cheryl H ArrowsmithMatthieu Schapira
Oct 21, 2015·Pharmacological Reports : PR·Robert KleszczWanda Baer-Dubowska
Mar 6, 2012·Biochimica Et Biophysica Acta·Raghunath Chatterjee, Charles Vinson
Oct 5, 2013·Autophagy·Haiqi LuHongchuan Jin
Apr 11, 2015·Clinical Epigenetics·Katarzyna Szarc vel SzicWim Vanden Berghe
Sep 25, 2014·Frontiers in Endocrinology·Paweł JóźwiakAnna Krześlak
Jul 5, 2016·Cancer Science·Shinjiro HinoMitsuyoshi Nakao
Feb 15, 2017·Frontiers in Human Neuroscience·Laetitia FrancelleKarine Merienne
Dec 20, 2017·International Journal of Molecular Sciences·Jorge S Burns, Gina Manda

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