The epigenetic calnexin-independent state is induced in response to environmental changes

FEMS Yeast Research
Renée GuérinLuis A Rokeach

Abstract

Yeasts have evolved numerous responsive pathways to survive in fluctuating and stressful environments. The endoplasmic reticulum (ER) is sensitive to adverse conditions, which are detected by response pathways to ensure correct protein folding. Calnexin is an ER transmembrane chaperone acting in both quality control of folding and response to persistent stress. Calnexin is a key protein required for viability in certain organisms such as mammals and the fission yeast Schizosaccharomyces pombe. Nevertheless, S. pombe calnexin-independent (Cin) cells were obtained after transient expression of a particular calnexin mutant. The Cin state is dominant, is stably propagated by an epigenetic mechanism and segregates in a non-Mendelian fashion to the meiotic progeny. The nucleolar protein Cif1p was identified as an inducer of the Cin state in a previous genetic screen. Here, we report the identification of novel inducers isolated in an overexpression genetic screen: pyruvate kinase (Pyk1p) and phosphoglycerate kinase (Pgk1p). Addition of pyruvate, the end product of pyruvate kinase and glycolysis, also induced calnexin independence in a dose-dependent manner. Remarkably, growth in respiration media or cold temperatures induced the appe...Continue Reading

References

Jul 25, 1992·Nucleic Acids Research·K Robzyk, Y Kassir
Jan 1, 1991·Methods in Enzymology·S MorenoP Nurse
Jan 1, 1972·Archiv für Mikrobiologie·H BauerE Sigarlakie
Jul 11, 1972·Biochemical and Biophysical Research Communications·F Foury, A Goffeau
Mar 3, 1995·The Journal of Biological Chemistry·M Jannatipour, Luis A Rokeach
Feb 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·O CantoniF Cattabeni
Mar 1, 1996·Molecular Microbiology·Margaret Werner-WashburneV M Peck
Jun 1, 1996·Current Opinion in Cell Biology·R M John, M A Surani
Apr 1, 1996·Current Opinion in Biotechnology·K Shinozaki, K Yamaguchi-Shinozaki
Sep 4, 1996·Biochemical and Biophysical Research Communications·A GuidarelliO Cantoni
Dec 20, 1996·Mechanisms of Ageing and Development·J E Riggs
Sep 25, 1998·Trends in Microbiology·P Gonçalves, R J Planta
Dec 10, 1999·Nature Cell Biology·M G Vander Heiden, C B Thompson
Dec 22, 1999·Seminars in Cell & Developmental Biology·Eric ChevetJ J Bergeron
Apr 25, 2000·Molecular and Cellular Biology·M H HarrisC B Thompson
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M G Vander HeidenC B Thompson
May 10, 2000·Molecular and Biochemical Parasitology·R S FelleisenB Gottstein
Sep 9, 2000·FEMS Microbiology Reviews·Carmen-Lisset FloresCarlos Gancedo
Feb 15, 2001·Cell Death and Differentiation·M H Harris, C B Thompson
Aug 4, 2001·Molecular and Cellular Biology·M G Vander HeidenC B Thompson
Dec 1, 2001·The EMBO Journal·A Müller-TaubenbergerG Gerisch
Feb 20, 2002·Biochemistry·Anna ZuppiniMarek Michalak
Aug 23, 2002·Functional & Integrative Genomics·Audrey P Gasch, Margaret Werner-Washburne
Oct 9, 2002·Molecular and Cellular Biology·Angela DenzelMichael J Owen
Nov 5, 2003·The Journal of Biological Chemistry·Steffen OhlmeierUlrich Bergmann
Feb 20, 2004·American Journal of Human Genetics·Peter Kraft
Jun 11, 2004·Annual Review of Biochemistry·Peter ChienAngela H DePace
Jun 19, 2004·Journal of Plant Physiology·Peeter TaltsOlav Keerberg
Jul 21, 2004·Current Opinion in Cell Biology·Bertrand Kleizen, Ineke Braakman
Aug 13, 2004·Proceedings. Biological Sciences·C L BrownK F A Walters
Dec 16, 2004·Journal of Biochemistry·Takenori TakizawaYoshinobu Nakanishi
Nov 1, 2005·Biochemical and Biophysical Research Communications·Wonhae LeeJoohong Ahnn
Jan 7, 2006·Cell Death and Differentiation·M Boyce, J Yuan
Jul 22, 2006·Cell Death and Differentiation·Frédéric DelomEric Chevet
Jan 5, 2007·Apoptosis : an International Journal on Programmed Cell Death·Frédéric DelomEric Chevet
May 8, 2007·FEBS Letters·Min Ni, Amy S Lee
Jan 25, 2008·The EMBO Journal·Tiziana Anelli, Roberto Sitia
Feb 7, 2008·The Journal of Biological Chemistry·Wolfgang ReiterCaroline R M Wilkinson
Feb 28, 2008·The Journal of Biological Chemistry·Julio J Caramelo, Armando J Parodi
Feb 29, 2008·Annual Review of Genetics·Shadia ZamanJames R Broach
Mar 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Carlos Gancedo, Carmen-Lisset Flores
Apr 18, 2008·PLoS Biology·Erin N Smith, Leonid Kruglyak
Aug 15, 2008·Molecular Biology of the Cell·Renée GuérinLuis A Rokeach
Oct 2, 2008·Cardiovascular Research·Georghia MichaelStanley Nattel
Dec 17, 2008·Annals of the Rheumatic Diseases·S M van der Maarel
Jul 17, 2009·PloS One·Renée GuérinLuis A Rokeach
Sep 5, 2009·Colloids and Surfaces. B, Biointerfaces·Cauê P PascholatiOsvaldo N Oliveira
Oct 7, 2009·Journal of Biosciences·Manoj K SharmaArun K Sharma

Citations

Jul 26, 2019·Seminars in Cell & Developmental Biology·Johannes Manjrekar, Hiral Shah

Related Concepts

Adaptation, Physiological
Cold Temperature
Yeast Proteins
Schizosaccharomyces pombe
Gene Expression Regulation, Fungal
Gene Dosage
Pyruvate
Calnexin
Epigenesis, Genetic
Virus Viability

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.