The epigenetic clock and pubertal, neuroendocrine, psychiatric, and cognitive outcomes in adolescents

Clinical Epigenetics
Anna SuarezKatri Räikkönen

Abstract

Molecular aging biomarkers, such as epigenetic age predictors, predict risk factors of premature aging, and morbidity/mortality more accurately than chronological age in middle-aged and elderly populations. Yet, it remains elusive if such biomarkers are associated with aging-related outcomes earlier in life when individuals begin to diverge in aging trajectories. We tested if the Horvath epigenetic age predictor is associated with pubertal, neuroendocrine, psychiatric, and cognitive aging-related outcomes in a sample of 239 adolescents, 11.0-13.2 years-old. Each year increase in epigenetic age acceleration (AA) was associated with 0.06 SD units higher weight-for-age, 0.08 SD units taller height-for-age, -0.09 SD units less missed from the expected adult height, 13 and 16% higher odds, respectively, for each stage increase in breast/genitals development on the Tanner Staging Questionnaire and pubertal stage on the Pubertal Development Scale, 4.2% higher salivary cortisol upon awakening, and 18 to 34% higher odds for internalizing and thought problems on the Child Behavior Checklist (p values <  0.045). AA was not significantly associated with cognition. Our findings suggest that already in adolescence, AA is associated with phys...Continue Reading

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Citations

Apr 12, 2020·Experimental Biology and Medicine·Kenneth Raj, Steve Horvath
Apr 20, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joanne RyanRobyn L Woods
Nov 28, 2019·Scientific Reports·Ellen WikeniusAnders Berglund
Dec 4, 2020·Schizophrenia Bulletin·Xiaohui WuCunyou Zhao
Jan 19, 2021·Biological Psychology·Marieke S TollenaarCarolina de Weerth
Feb 10, 2021·Brain Sciences·Tanya Van AswegenBenjamin L Hankin
Apr 10, 2021·Scientific Reports·Angelica Cerveira de BaumontGisele G Manfro
Aug 11, 2021·Clinical Epigenetics·Jane MaddockRebecca Hardy

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Methods Mentioned

BETA
MDS
genotyping
chip

Software Mentioned

SPSS
IMPUTE2

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