The Epigenetic Impact of Cruciferous Vegetables on Cancer Prevention

Current Pharmacology Reports
Kendra J Royston, Trygve O Tollefsbol

Abstract

The answer to chemoprevention has perhaps been available to the general public since the dawn of time. The epigenetic diet is of extreme interest, for research suggests that cruciferous vegetables are not only an important source of nutrients, but perhaps a key to eliminating cancer as life threatening disease. Cruciferous vegetables such as kale, cabbage, Brussels sprouts, and broccoli sprouts contain chemical components, such as sulforaphane (SFN) and indole-3-carbinol (I3C), which have been revealed to be regulators of microRNAs (miRNAs) and inhibitors of histone deacetylases (HDACs) and DNA methyltransferases (DNMTs). The mis-regulation and overexpression of these genes are responsible for the uncontrolled cellular proliferation and viability of various types of cancer cells. The field of epigenetics and its incorporation into modern medicinal investigation is an exponentially growing field of interest and it is becoming increasingly apparent that the incorporation of an epigenetic diet may in fact be the key to chemoprevention.

References

Jan 1, 1995·Natural Toxins·J P WatheletP J Wagstaffe
Jul 4, 2003·The Journal of Nutrition·Karen J AubornTimothy H Carter
Aug 18, 2004·Cancer Research·Melinda C MyzakRoderick H Dashwood
Feb 1, 2005·The Journal of Nutritional Biochemistry·Young S Kim, J A Milner
Jan 27, 2006·World Journal of Gastroenterology : WJG·Peter RoseMatt Whiteman
Feb 21, 2006·The Journal of Nutritional Biochemistry·Thomas T Y WangYoung S Kim
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Feb 24, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jane V HigdonRoderick H Dashwood
Mar 7, 2007·Molecular Cancer Therapeutics·Allison Pledgie-TracyNancy E Davidson
Aug 29, 2007·Acta Pharmacologica Sinica·Yuesheng Zhang, Li Tang
Feb 22, 2008·The Journal of Nutrition·Andrea Y Arikawa, Daniel D Gallaher
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Li TangSusan E McCann
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Angela GibbsJoshi Alumkal
Oct 9, 2009·The Journal of Nutrition·Emily HoRoderick H Dashwood
Jul 1, 1946·The Medical Clinics of North America·E A HINES
Aug 3, 2011·Molecular Pharmacology·Sivaprakasam BalasubramanianRichard L Eckert
Oct 1, 2011·Journal of Cellular Biochemistry·Kozue Sakao, Shivendra V Singh
May 30, 2012·Biochimica Et Biophysica Acta·Aleksandra WiczkAnna Herman-Antosiewicz
Aug 28, 2012·Journal of Industrial Microbiology & Biotechnology·Alicja B VeseláLudmila Martínková
Oct 25, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Huitao FanMehmet Ulas Cinar
Mar 19, 2013·Journal of Clinical Bioinformatics·Rishabh KalaTrygve O Tollefsbol
Jun 5, 2013·Nutrition Reviews·Lin LinPeter J H Jones

❮ Previous
Next ❯

Citations

Feb 9, 2016·Seminars in Cancer Biology·Nagendra Sastry YarlaGovinda Rao Duddukuri
Apr 6, 2016·Veterinary and Comparative Oncology·V L RizzoJ J Wakshlag
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Silvia NovíoMaría Jesús Núñez-Iglesias
Aug 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marius Alexandru MogaLiana Ples
Oct 27, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·John A Halsall, Bryan M Turner
Mar 28, 2017·Journal of Biochemical and Molecular Toxicology·Kewei RenXinwei Han
Jun 9, 2017·Molecular Nutrition & Food Research·Verónica Del Carmen Martínez-JiménezDiana Patricia Portales-Pérez
Nov 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kateřina LněničkováIva Boušová
Mar 21, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Chun-Xiao LuDong-Xu He
Aug 7, 2018·Molecular Nutrition & Food Research·Besma AbbaouiAmir Mortazavi
Jan 12, 2017·International Journal of Molecular Medicine·Akari MinamiSatoru Matsuda
Oct 28, 2019·Foods·Luz A ChoquechambiEduardo O Leidi
Jul 4, 2019·Current Pharmaceutical Design·Dominik KołodziejskiAgnieszka Bartoszek
Oct 31, 2019·World Journal of Gastrointestinal Oncology·Kendra J RoystonOlufunmilayo I Olopade
Apr 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sarai Quirante-MoyaDiego A Moreno
Nov 3, 2020·Food Science & Nutrition·Zinian WangLi Tang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rita M MoraesMiriam V Lourenço
Jun 5, 2021·Neurobiology of Disease·Miguel A PappollaBurkhard Poeggeler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.