The epigenetic silencing of the estrogen receptor (ER) by hypermethylation of the ESR1 promoter is seen predominantly in triple-negative breast cancers in Indian women.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jyothi S PrabhuT S Sridhar

Abstract

The proportion of estrogen receptor (ER)-negative and triple-negative (TN) breast cancer in Indian women is higher than that reported in the West, and this difference persists even after their migration to the West. The causes for this significant difference are not entirely clear. Hypermethylation of the ER promoter, an epigenetic alteration, is known to be one of the mechanisms by which the expression of ER is suppressed. Two thirds of breast cancer specimens from an Indian center tested, using the highly sensitive, methylation-specific polymerase chain reaction (MSP) technique, were reported positive. We have used a quantitative assay, the MethyLight, to better assess the extent of methylation in the ESR1 promoter region in 98 breast cancer tumor specimens from Indian women. In addition, the amount of ER transcripts was determined by quantitative reverse transcriptase polymerase chain reaction. Using the stringent cutoff of at least 4% of the target sequence being methylated, 27% of TN tumors were methylated. In addition they demonstrated the highest levels of methylation. In contrast less than 2% ER-positive tumors were hypermethylated. While the proportion of hypermethylated tumors are lower in this study than that estimat...Continue Reading

References

Jun 20, 1990·Journal of the National Cancer Institute·W L McGuireG M Clark
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Mar 29, 2000·Nucleic Acids Research·C A EadsP W Laird
Aug 15, 2001·Journal of Mammary Gland Biology and Neoplasia·L YanN E Davidson
Sep 28, 2001·Japanese Journal of Clinical Oncology·W AjikiUNKNOWN Research Group For Population-Based Cancer Registration in Japan
Jan 21, 2004·The Breast : Official Journal of the European Society of Mastology·S B DesaiR F Chinoy
May 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Roman RouzierLajos Pusztai
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roman RouzierLajos Pusztai
Mar 21, 2007·European Journal of Cancer Care·N S MurthyS Saxena
Mar 28, 2007·World Journal of Surgery·Gaurav AgarwalPolly S Y Cheung
Apr 18, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa A CareyCharles M Perou
Mar 27, 2009·Breast Cancer Research : BCR·Lesley A SteadCarol L Rosenberg
Apr 1, 2009·Indian Journal of Pathology & Microbiology·Tanuja ShetR F Chinoy
Oct 29, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mia M GaudetMark E Sherman
Jun 23, 2010·Breast Cancer Research : BCR·Karolina HolmMarkus Ringnér
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jurgen VeeckManel Esteller
Oct 6, 2010·Breast Cancer Research : BCR·Naiara G BediagaMarian M de Pancorbo
Dec 16, 2010·The Oncologist·Charles M Perou
May 17, 2011·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Alok Kumar SinghHausila Prasad Pandey

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Citations

May 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shilpi ChattopadhyaySyed Akhtar Husain
Jul 8, 2014·Neurobiology of Disease·Irfan A Qureshi, Mark F Mehler
Aug 16, 2014·Biochemical and Biophysical Research Communications·Timothy M Barrow, Karin B Michels
Jan 7, 2015·International Journal of Cancer. Journal International Du Cancer·Timothy M BarrowKarin B Michels
Dec 30, 2014·Cell Biochemistry and Biophysics·ZiQi TaoJing Zhao
Feb 1, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Eric HervouetRégis Delage-Mourroux
Dec 23, 2014·Epigenomics·Seher Karsli-CeppiogluDominique Bernard-Gallon
May 5, 2016·Molecular Nutrition & Food Research·Donato F RomagnoloOrnella I Selmin
Mar 24, 2018·Veterinary Pathology·Yara de Oliveira BrandãoGiseli Klassen
Mar 25, 2020·Critical Reviews in Biochemistry and Molecular Biology·Linxi LiC Yan Cheng
Nov 17, 2020·Frontiers in Oncology·Pedro Luiz Porfirio XavierHeidge Fukumasu
Jun 5, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sunil Kumar DubeyPrashant Kesharwani

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