journal cover

The epigenetics of aging and neurodegeneration

Progress in Neurobiology

Jun 15, 2015

Roy LardenoijeBart P F Rutten

Abstract

Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing relevance to neuroscience, with epigenetic mechanisms being implicated in brain development and neuronal differentiation, a...read more

Mentioned in this Paper

Hippocampus (Brain)
Histone Deacetylase
Histone H3
Histones
HIV-1
ABCA1 gene
ADAM10 gene
ADAM17 gene
ADAR gene
ADARB1 gene
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1
399
Paper Details
References
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Mitochondrial metabolism links energy production to other essential cellular processes such as signaling, cellular differentiation, and apoptosis. Discover the latest research here.

Mitochondrial Malfunction & Autophagy

Autophagy is thus a key determinant for mitochondrial health and proper cell function. In addition to autophagy's significance in mitochondrial integrity, several lines of evidence suggest that mitochondria can also substantially influence the autophagic process.

Epigenetic Regulation of Microglia Functions

Microglial cells are instrumental in the maintenance of homeostasis in the CNS and can contribute to neurodegenerative disorders. Epigenetic mechanisms and transcriptional regulation may be potential therapeutic targets for their activation or suppression. Discover the latest research on epigenetic regulation of microglial functions here.

Eukaryotic RNA Polymerase III

Eukaryotic RNA polymerase III (RNAP III) is a multisubunit enzyme responsible for transcribing tRNA, 5S rRNA, and several small RNAs. Here is the latest research.

Embryonic Neural Stem Cells

Embryonic neural stem cells can be used to investigate the effect of different toxins and molecules on the proliferation and differentiation of these cells. Discover the latest research of embryonic neural stem cells here.

Alzheimer's Disease: Neuroimaging

Alzheimer's disease (AD) is a chronic neurodegenerative disease. Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

G-Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research.

Tauopathies

Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. Discover the latest research on tauopathies here.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Neuroscience: Genomics

Neuroscience integrates data from anatomical, biological, developmental, and mathematical models to understand the nervous system. Here is the latest research on genomics in neuroscience.

Chromatin Remodeling (Keystone)

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying this process.

Signal Transduction & Gene Expression (Keystone)

Tumor cells have their own unique signal transduction and gene expression control. Targeting these specific cellular mechanisms and genetic proflies of cancer cells is an area of therapeutic exploration for some cancers. Discover the latest research on this topic with this feed.

Cytoskeleton & Cell Polarity

A dynamic cytoskeleton is critical for the generation of cell polarity. This feed focuses on cell polarity and the cytoskeleton, including actin and microtubular cytoskeletal organization.

CpG Sites

CpG sites are genomic loci where cytosine is followed by a guanine along its 5’ to 3’ direction. CpG sites are common in CpG islands and its methylation has been implicated in cancer, aging, and gene silencing. Here is the latest research.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Embryonic Development: Enhancer/Promoter(Keystone)

During development and differentiation of an organism, accurate gene regulation is central for cells to maintain and balance their differentiation processes. Transcriptional interactions between cis-acting DNA elements such as promoters and enhancers are the basis for precise and balanced transcriptional regulation.This feed follows research on enhancer promoter communication in embryonic development.

Alzheimer's Disease: Animal models

Alzheimer's disease is a chronic neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Ubiquitin System

Ubiquitin is a small regulatory protein that is attached to proteins as a post-translational modification in a process known as ubiquitination to regulate protein turnover, location, or activity. Here is the latest research on the ubiquitin system.

Alzheimer's Disease: APP

Amyloid precursor protein proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques. Here is the latest research.

Phosphoproteomics

Phosphoproteomics refers to the identification and quantification of phosphorylated proteins in the proteome. This approach provides a high-throughput method of examining the state of intracellular phosphorylation. Here is the latest research on phosphoproteomics.

mtDNA Transcription

mtDNA transcription generates the necessary RNAs that encode several protein subunits involved in the oxidative phosphorylation process. Here is the latest research. 


Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

Histone Methyltransferases

Histone methyltransferases, as chromatin modifiers, regulate the transcriptomic landscape in normal development as well in diseases such as cancer. Here is the latest research.

Organelles in Neurodegeneration

Neurodegeneration is the progressive loss of neural structures and functions, including neuronal death. This feed focuses on dynamics of neuronal organelles in neurodegenerative diseases.

Insulin, Astrocytes & Depressive Behaviour

Insulin regulates astrocyte gliotransmission and dopaminergic neurotranmission. As a result, insulin resistence has been associated with behavioural and mood symptoms such as depression. Here is the latest research on Insulin, Astrocytes & Depressive Behaviour.

Chromatin Remodelling

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.

Triplet Repeat Disorders

Triplet Repeat Disorders are genetic disorders that occur as a result of expansion of trinucleotide repeats in certain genes. Examples include Huntington’s disease, certain types of spinocerebellar ataxia, and Fragile X syndrome, among others. Here is the latest research.

Global Screens and Gene Activity (Keystone)

Genome-wide screen allows researchers to look at the whole picture of gene activity that is going on in the cell. Discover the latest research here.

Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Cytoskeletal Collection

The cytoskeleton is a dynamic network of interlinking protein filaments that extends from the plasma membrane to the nucleus. Here is the latest research.

Mammalian Cell Cycle & Cell Growth Control

Mammalian cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of mammalian cell cycle and growth.

Astrocytes & Amyloid

The relationship between astrocytes and amyloid has been suggested in some neurological diseases such as Alzheimer’s disease. Neuronal damage stimulates the activation of reactive astrocytes, which may the source of amyloid that forms in Alzheimer’s. Here is the latest research on astrocytes and amyloid.

Neurodegeneration: Endolysosome

This feed focuses on the role of the endolysosome, an organelle involved in protein degradation. Defects in the endolysosome may cause neurodegenerative diseases, such as Alzheimer’s Disease.

Stem Cells in Neurodegenerative Diseases

Stem cells have the potential to develop into many different types of cells in the body and may be useful as a therapy for several diseases including neurodegenerative diseases. Discover the latest research on stem cells and neurodegenerative diseases here.

MicroRNAs & Open Reading Frames

MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs & how they target Open Reading Frames.

Dopamine & Behavior

Dopamine is a neurotransmitter and a hormone commonly associated with the brain's pleasure and reward system. Here is the latest research on its role in affecting and guiding human behaviour.

Cerebellar Neoplasms

Tumors within the cerebellum of the brain can be malignant or benign. This is often a secondary site for metastasis from other cancers, including lung and breast cancer. Symptoms of cerebellar tumors include ataxia and intracranial hypertension. Here is the latest research on cerebellar neoplasms.

iPSC-derived Microglia in Neurodegeneraton

Induced pluripotent stem cell-derived microglia have recently been developed and provide unlimited access to patient-derived material. These cells can be used to model and investigate mechanism that underlie neurodegenerative diseases. Here is the latest research.

PTMs of Transcription Factors

This feed focuses on post-translational modifications (PTMs) that occur on transcription factors, which may affect transcriptional processes.

Cytoskeleton & Cell Polarity

A dynamic cytoskeleton is critical for the generation of cell polarity. This feed focuses on cell polarity and the cytoskeleton, including actin and microtubular cytoskeletal organization.

Chromatin Regulators: Differentiation (Keystone)

Chromatin regulators affect gene expression by influencing the access of proteins such as transcription factors to DNA. Here is the latest research on the role of chromatin regulating proteins in cellular differentiation.

Mitochondrial Ros

PSCs in Development and Disease

Pluripotent stem cells (PSCs) are progenitor cells that can give rise to three basic layers of the body, thus potentially allowing the production of any cells or tissues needed by the body for repair. Here is the latest research on the PSCs in development and disease.

DNA Methylation (Keystone)

DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.

Dementia & Neurodegenerative Diseases

This feed focuses on the impact of insulin resistance, caloric restriction, cytokine singling, and metabolism on dementia and neurodegenerative diseases. Here is the latest research in this domain.

REDOX Signaling in Aging

The redox theory of aging is that aging is a decline in plasticity of genome-exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.

Histone Modifications

Histone modifications, including acetylation, phosphorylation, and methylation, play important roles in regulating chromatin structure and nuclear processes. They can also be passed to daughter cells as epigenetic marks. Here is the latest research on histone modification.

Histone Deacetylases

Histone deacetylases (HDACs) are a class of chromatin modifying enzymes that remove specific acetyl groups from histones, allowing the histones to wrap DNA more tightly, thus leading to alterations in gene expression. Here is the latest research. 


Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Ubiquitination Pathways &Therapeutics (Keystone)

The addition of ubiquitin to a protein substrate via a multistep process is referred to as ubiquitination, which can have a variety of different effects on the protein including flagging the protein for degradation, altering its location or activity, or altering protein-protein interactions. Dysreguation of this pathway has been implicated in multiple disease processes. Here is the latest research on ubiquitin pathways and targeted degradation.

RNA-induced Silencing Complex (Keystone)

The RNA-induced Silencing Complex mediates gene silencing through direct mRNA degradation or translational inhibition. Discover the latest research on the RNA-induced Silencing Complex in this feed.

Nucleosome Positioning (Keystone)

Nucleosome positioning influences transcription by regulating the chromatin accessibility of the transcriptional machinery and chromatin remodeling proteins. Discover the latest research on nucleosome positioning here.

Stem And Cancer Cells (Keystone)

The cancer stem cell theory proposes that, in tumors, there exist a sub-population of cells that possess characteristics of normal stem cells, specifically the ability to self-renew, and that these cells proliferate and sustain the cancer. Here is the latest research on stem and cancer cells.

Epigenetic Regulation of Neural Development

Epigenetic regulation involves chromatin remodeling complexes that catalyze DNA methylation changes and various types of histone modifications that can influence the expression of genes involved in neural development. Discover the latest research on the epigenetic regulation of neural development here.

Cardiovascular Disease & TET2

Cardiovascular diseases are the number one cause of deaths globally. Tet methylcytosine dioxygenase 2 (TET2)-mediated hematopoiesis has been implicated in accelerating heart failure. Here is the latest research on cardiovascular diseases and TET2.

Epigenetics & Aging

Epigenetic changes, such as changes in histone modification patterns and noncoding RNA expression levels, have a strong influence on the aging process. Discover new insights into the role of epigenetics in aging in this feed.

Non-coding Variants in Cancer

Mutations, single nucleotide variants and large genomic rearrangements, in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. Here is the latest research.

Stem Cell Aging

Aging tissues experience a progressive decline in homeostatic and regenerative capacities, which has been attributed to degenerative changes in tissue-specific stem cells, stem cell niches and systemic cues that regulate stem cell activity. Understanding the molecular pathways involved in this age-dependent deterioration of stem cell function will be critical for developing new therapies for diseases of aging that target the specific causes of age-related functional decline.

Innate Immunity: Neurodegeneration

The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

EP300 & Neuroblastoma (Keystone)

EP300 is a histone acetyltransferase protein that regulates the transcription of genes via chromatin remodeling. EP300 is also a tumour suppressing protein with essential roles in regulating cell growth, division, differentiation. Here is the latest research on EP300 in high-risk neuroblastoma.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Neuronal Cell Types

There are diverse ranges of neurons, which are defined by their structural, functional, connectional and molecular properties. For example, some type of neurons includes sensory, sympathetic, and motor neurons. Discover the latest research on neuronal cell types here.

Signal Transduction & Control of Gene Expression

Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Muscle Mitochondrial Networks

This feed focuses on the role of mitochondrial networks and energy metabolism in muscle cells. Discover the latest research here.

PGC-1a & Target-Gene Expression (Keystone)

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) or PPARGC1A is a transcriptional coactivator and is known for regulating mitochondrial biogenesis. Discover the latest research on PGC-1a and target-gene expression in this feed.

siRNA CNS Silencing

Small interfering RNA (siRNA) are double-stranded RNA molecules that operate in the RNA interference pathway. Here is the latest research on silencing of genes in the central nervous system using siRNAs.

Age-related Dementia

Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Discover the latest research on age-related dementia here.

Huntington Disease

Huntington disease is a hereditary neurodegenerative disease characterized by poor coordination and involuntary body movements. Discover the latest research on Huntington disease here.

Epigenetics (Keystone)

Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here is the latest research.

Parkinson's Disease: Genetics

Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on genetic screening approaches and genetic predispositions in Parkinson’s disease.

RNA Hairpin in Yeast

Short hairpin RNA are used to interrogate gene function in model organisms. Discover the latest research in RNA hairpins in Yeast.

Transposons for Gene Editing

Transposons can replicate and spread through the host’s genome and therefore be used as a genetic tool for analysis of gene function. Discover the latest research on the use of transposons for gene editing here.

Alzheimer's Disease: Genes&Microglia

Genes and microglia are associated with the risk of developing and the progression of conditions such as Alzheimer's Disease (AD). Here are the latest discoveries pertaining to this disease.

Stem And Cancer Cells

The cancer stem cell theory proposes that, in tumors, there exist a sub-population of cells that possess characteristics of normal stem cells, specifically the ability to self-renew, and that these cells proliferate and sustain the cancer. Here is the latest research on stem and cancer cells.

Genetic Influences on Brain Development

The genetic landscape of an individual can have drastic effects on brain development and brain developmental disorders. Discover the latest research here.

Inosine: Parkinson's Disease

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects movement. Drug Inosine is proposed to slow progression of this disease. Here is the latest research on Inosine in PD.

Gene Regulation, Epigenetics, & Aging (Keystone)

Epigenetic and genetic factors influence aging processes and age-associated diseases. Manipulation of epigenetic changes may prove to be a useful therapeutic tool. Find the latest research relating to Shelley Berger's talk on "Epigenetic Pathways as Targets in Human Cancer" in this feed.

Induced Pluripotent Stem Cells (Keystone)

Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors, These cells have similar properties to those of embryonic stem cells (ESCs) but bypass the ethical concerns of embryo destruction and can be exploited for both research and clinical applications. Discover the latest research related to the talk on "OGT, a Nutrient-Sensing Enzyme, Controls DNA Methylation in Mouse Embryonic Stem Cells" here.

RNA & Tau in Frontotemporal Dementia

Tau mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) are associated with changes in alternative RNA splicing. Here is the latest research on RNA & Tau in Frontotemporal Dementia.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Lewy Body Disease

Lewy Body Disease, associated with abnormal deposits of proteins like alpha-synuclein in the brain, causes a decline in mental abilities. Here is the latest on this progressive neurological disorder.

Nucleosome Positioning

Nucleosome positioning influences transcription by regulating the chromatin accessibility to transcriptional machinery and chromatin remodelling proteins. Discover the latest research on Nucleosome Positioning here.

Neuroblastoma in Zebrafish

This feed focuses on neuroblastoma in Zebrafish, as well as MYCN and ALK oncogenes which are highly expressed in neuroblastoma. Here is the latest research.

LRRK2 Inhibitors

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease. Increased kinase activity of certain LRRK2 mutants is thought to underlie dopaminergic neuron damage. Thus, LRRK2 inhibitors offer the potential to target an underlying cause of the disease. Here is the latest research.

Interferon Stimulated Genes

Interferon-stimulated gene products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. Discover the latest research on interferon-stimulated genes here.

Glial Cell Differentiation

Glial cells play an essential role in maintaining brain homeostasis, forming myelin, and providing support and protection for neurons. Follow new research into glia cell differentiation with this feed.

Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

RNA-induced Silencing Complex

The RNA-induced Silencing Complex mediates gene silencing through direct mRNA degradation or translational inhibition. Discover the latest research on the RNA-induced Silencing Complex here.

Neuronal Remodeling

Neuronal remodeling is a critical step in the development of the mature nervous system and important in the refinement to respond to developmental and environmental influences. Disruption of this process can lead to neuropsychiatric diseases. Here is the latest research on neuronal remodeling.

Epigenome Engineering

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of dna methylation. Discover the latest research here.

ROS: Metabolism & Signaling

Reactive oxygen species (ROS) are reactive chemicals containing oxygen. They generated as a byproduct of oxidative energy metabolism and play a role in regulating several intracellular signaling pathways. Here is the latest research on ROS metabolism and signaling.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.

Astrocytes and Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Neural Stem Cell Maintenance

Poly(ADP-Ribose) Polymerases

Poly(ADP-Ribose) Polymerase (PARP) is an enzyme with several functions, including cell differentiation, proliferation, and DNA damage repair. Here is the latest research on PARP.

Insulin, Astrocytes & Depressive Behavior

Insulin regulates astrocyte gliotransmission and dopaminergic neurotranmission. As a result, insulin resistence has been associated with behavioral and mood symptoms such as depression. Here is the latest research on insulin, astrocytes & depressive behavior.

MAPK Pathway

MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.

Epigenome Engineering (Keystone)

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of DNA methylation. Discover the latest research here.

ROS & Mitochondria

Reactive oxygen species can be generated during mitochondrial processes including oxidative phosphorylation and can contribute to DNA damage. Here is the latest research on ROS and mitochondria.

Neural Stem Cell Quiescence

Movement Disorders

Movement disorders are a group of nervous system disorders that increase or decrease voluntary or involuntary movements. Here is the latest research on genetic and environmental factors, as well as mechanisms that underlie movement disorders.

Microglia: Health and Disease

Microglia are the resident macrophages of the central nervous system. Microglia-derived inflammatory neurotoxins play a principal role in the pathogenesis of several neurodegenerative disorders. Here is the latest research on the role of microglia in health and disease.

Microtubules & Microtubule-Associated Proteins (Keystone)

Microtubule organization and dynamics are regulated by microtubule-associated proteins that interact with microtubules to regulate dynamic instability. Here is the latest research on microtubules and microtubule-associated proteins.

Post-transcriptional RNA modifications

Post-transcriptional RNA modifications can be dynamic and might have functions beyond fine-tuning the structure and function of rna.

Mitochondria Protein Regulation

There is emerging evidence that mitochondria are involved in post-translational modifications and may be involved in metabolic diseases. Discover the latest research on mitochondria protein regulation.

Neuronal Identity

Neuronal identity is important for defining the end result of stem cell differentiation through neuronal developmentor for regenerative medicine. This could involved transcription factors used to drive induce pluripotent stem cells towards the neuronal lineage. Discover the latest research on Neuronal Identity here.

Proliferation & Neurodevelopmental Disorders

To form the complex network of the CNS, there is a synchronous flow of proliferation, migration and differentiation of neuronal cells. When errors in these processes occur, it is thought to be a contributing factor to cognitive deficits and neurodevelopmental disorders. Here is the latest research on proliferation and neurodevelopmental disorders.

Germline Stem Cells

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

Neural Fate Specification

Neural stem cells are self-renewing, multipotent cells that are present in both the embryonic and adult brain. Several factors, including metabolism, have been shown to regulate proliferation, differentiation, and quiescence of neural stem cells. Here is the latest research.

Metabolite Signals in Aging

Aging leads to the loss of cellular homeostasis, a decline in physiological function and an increase on pathological substrates. Some of these substrates may include metabolites that may accumulate in tissues and disrupt normal functioning. Discover the latest research on metabolite signals in aging here.

Protein Kinases & Mitosis

Phosphorylation-dependent changes orchestrate almost every step of cell division, from entry into mitosis to cytokinesis. These changes are mediated by several different protein kinases, including the Aurora and Cyclin-dependent kinases. Here is the latest research examining the role of protein kinases in mitosis.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Hereditary Cancer Syndromes

Hereditary cancer syndromes comprise 5% of all cancers and have an increased risk of early onset and of multiple or bilateral malignancies. Here is the latest research on hereditary cancer syndromes.

Epigenetic Regulation of Neural Development (Keystone)

Epigenetic regulation involves chromatin remodeling complexes that catalyze DNA methylation changes and various types of histone modifications that can influence the expression of genes involved in neural development. Discover the latest research on the epigenetic regulation of neural development here.

Global Screens and Gene Activity (Keystone)

Genome-wide screens allow researchers to look at the whole picture of gene activity that is going on in the cell. Discover the latest research using genome-wide screens in this feed.

RNAi & Gene Silencing

RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.

Histone Deacetylases (Keystone)

Histone deacetylases (HDACs) are a class of chromatin-modifying enzymes that remove specific acetyl groups from histones, allowing the histones to wrap DNA more tightly, thus leading to alterations in gene expression. Here is the latest research on HDACs including SIRT6.

Misfolded Proteins: ND

Protein misfolding is the primary cause of several neurodegenerative disease, including Alzheimer’s and Parkinson’s disease. Here is the latest research.

Epigenetics & Psychiatry

Psychiatric disorders are known to be multifaceted in their pathophysiology. Because epigenetic changes can be sensitive to the environment, inherited, and reversible, the study of epigenetics in psychiatric disease is a logical way to understand the natural history of the disease as well as to develop therapeutics. Find the latest research on epigenetics and psychiatry here.

Dna Damage Response

© 2020 Meta ULC. All rights reserved

The epigenetics of aging and neurodegeneration

Progress in Neurobiology

Jun 15, 2015

Roy LardenoijeBart P F Rutten

PMID: 26072273

DOI: 10.1016/j.pneurobio.2015.05.002

Abstract

Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing relevance to neuroscience, with epigenetic mechanisms being implicated in brain development and neuronal differentiation, a...read more

Mentioned in this Paper

Hippocampus (Brain)
Histone Deacetylase
Histone H3
Histones
HIV-1
ABCA1 gene
ADAM10 gene
ADAM17 gene
ADAR gene
ADARB1 gene
7
1
399

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