The epigenetics of germ-line immortality: lessons from an elegant model system.

Development, Growth & Differentiation
Hirofumi Furuhashi, William G Kelly

Abstract

Epigenetic mechanisms are thought to help regulate the unique transcription program that is established in germ cell development. During the germline cycle of many organisms, the epigenome undergoes waves of extensive resetting events, while a part of epigenetic modification remains faithful to specific loci. Little is known about the mechanisms underlying these events, how loci are selected for, or avoid, reprogramming, or even why these events are required. In particular, although the significance of genomic imprinting phenomena involving DNA methylation in mammals is now well accepted, the role of histone modification as a transgenerational epigenetic mechanism has been the subject of debate. Such epigenetic mechanisms may help regulate transcription programs and/or the pluripotent status conferred on germ cells, and contribute to germ line continuity across generations. Recent studies provide new evidence for heritability of histone modifications through germ line cells and its potential effects on transcription regulation both in the soma and germ line of subsequent generations. Unraveling transgenerational epigenetic mechanisms involving highly conserved histone modifications in elegant model systems will accelerate the g...Continue Reading

References

Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·L XuS Strome
Sep 24, 2004·Current Biology : CB·Laurel B BenderSusan Strome
Dec 1, 2004·Annual Review of Genetics·Leonie Ringrose, Renato Paro
Mar 31, 2005·Molecular and Cellular Biology·Kaoru TominagaOlivia M Pereira-Smith
Jun 1, 2005·Molecular and Cellular Biology·Kaoru TominagaOlivia M Pereira-Smith
Apr 4, 2006·Molecular and Cellular Biology·David G E MartinLeAnn Howe
Apr 25, 2006·Current Biology : CB·Masamitsu FukuyamaJoel H Rothman
Nov 30, 2006·Cell·Geraldine Seydoux, Robert E Braun
Feb 27, 2007·Cell·Bing LiJerry L Workman
Feb 27, 2007·Cell·M Azim SuraniPetra Hajkova
Jun 19, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tomohiro HayakawaJun-ichi Nakayama
Aug 4, 2007·Science·Magnolia BostickSteven E Jacobsen
Jan 17, 2008·Nature Reviews. Genetics·Hiroyuki Sasaki, Yasuhisa Matsui
May 30, 2008·Current Opinion in Cell Biology·Ali Shilatifard
Sep 6, 2008·Nature·Hideharu HashimotoXiaodong Cheng
Oct 22, 2008·Nature Cell Biology·Klaus H HansenKristian Helin
Jun 16, 2009·Nature·Saher Sue HammoudBradley R Cairns
Sep 22, 2009·Nature·Raphael MargueronSteven J Gamblin
Mar 2, 2010·Current Biology : CB·Tetsuya MuramotoJonathan R Chubb

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Citations

May 28, 2014·Integrative and Comparative Biology·Pamela A PadillaLee S Toni
Jan 1, 2012·Worm·Bérénice A Benayoun, Anne Brunet
Feb 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kan XieDan Ehninger
May 14, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Michael K SkinnerJohn R McCarrey
Jul 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Xinya HuangXuezhu Feng

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