The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics

Pharmacogenomics
Gerald A HigginsBrian D Athey

Abstract

The 4D nucleome has the potential to render challenges in neuropsychiatric pharmacogenomics more tractable. The epigenome roadmap consortium has demonstrated the critical role that noncoding regions of the human genome play in determination of human phenotype. Chromosome conformation capture methods have revealed the 4D organization of the nucleus, bringing interactions between distant regulatory elements into close spatial proximity in a periodic manner. These functional interactions have the potential to elucidate mechanisms of CNS drug response and side effects that previously have been unrecognized. This perspective assesses recent advances likely to reveal novel pharmacodynamic regulatory pathways in human brain, charting a future new avenue of pharmacogenomics research, using the spatial and temporal architecture of the human epigenome as its foundation.

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Citations

Apr 8, 2017·Methods : a Companion to Methods in Enzymology·Gerald A HigginsBrian D Athey
Apr 27, 2018·Pharmacogenomics·Alexandr A KalininBrian D Athey
Sep 14, 2018·Scientific Reports·Alexandr A KalininIvo D Dinov
Jun 25, 2021·Sleep Medicine Reviews·Nathaniel F Watson, Christopher R Fernandez
Apr 29, 2021·Molecular Biology of the Cell·Alexandr A KalininBrian D Athey
Dec 31, 2017·Gastroenterology·Lin ChangJohn W Wiley

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Methods Mentioned

BETA
Hi-C
RNA-seq
immunoprecipitation
proximity ligation
pulldown
single cell sequencing
PCR
GTPase

Software Mentioned

ENCODE
HUGO
Hi
TransFac

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