PMID: 3751991Sep 1, 1986Paper

The epithelial antigen phenotype of glomerular crescent cells

American Journal of Clinical Pathology
J C Jennette, C G Hipp

Abstract

There is controversy over the origin of cells in glomerular crescents. Although crescent cells were once considered to be of epithelial lineage, recent data have suggested that they are derived from the mononuclear phagocyte system. To further define the histogenesis of crescents, the authors evaluated 26 renal biopsy specimens having cellular crescents, using immunoenzyme and immunofluorescence microscopy, and a battery of 11 antibodies reactive with renal epithelial cells and 5 antibodies reactive with leukocytes. Although minor populations of macrophages were present in most crescents, in only 1 of 23 specimens evaluated with anti-macrophage antibodies were these the major cell type. Of 23 specimens evaluated with anti-epithelial antibodies, all but one had crescents with most of the cells expressing one or more epithelial antigens. Crescent cells shared antigens with glomerular and tubular epithelial cells, but the antigen phenotype of crescents often differed from that of normal tubular or glomerular epithelial cells.

Citations

Apr 29, 2009·Nature Reviews. Nephrology·Min ChenMing-Hui Zhao
Oct 10, 2008·American Journal of Physiology. Renal Physiology·Andrej SkoberneMario Schiffer
Sep 12, 2018·The American Journal of Pathology·Ania ProchnickiChristoph Daniel
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Michel LE HirWilhelm Kriz
Mar 13, 2003·Kidney International·J Charles Jennette
Jan 28, 2005·Kidney International·Wilhelm Kriz, Michel LeHir

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