The epithelium in acute lung injury/acute respiratory distress syndrome

Current Opinion in Critical Care
Michael A Gropper, Jeanine Wiener-Kronish

Abstract

The mechanisms of epithelial injury in acute lung injury/acute respiratory distress syndrome have been of interest since the syndrome was first described. Cell therapies to replace injured epithelium are a futuristic dream; however, there is ongoing research to achieve this goal. We review research regarding the function of the epithelium in acute lung injury/acute respiratory distress syndrome, including potential novel therapies. Altered fluid clearance from the injured lungs in acute lung injury/acute respiratory distress syndrome patients has been consistently found and is an important prognostic finding. New research suggests that neutrophils that enter the lung late and which are enticed into the lung through a specific chemokine system may be important for causing lung injury. If this is the case, then blockers of this system could be a possible therapy. The role of fibrinolysis and coagulation abnormalities in lung injury due to infection and other perturbations is examined. These abnormal findings may be useful diagnostic tools for prognostication as well as targets for future therapies. Epithelial damage is a hallmark of acute lung injury/acute respiratory distress syndrome. An increased understanding of the function ...Continue Reading

References

Dec 1, 1990·The American Review of Respiratory Disease·M A Matthay, J P Wiener-Kronish
Aug 1, 1987·American Journal of Hematology·A C CarvalhoW M Zapol
Jun 1, 1988·The American Review of Respiratory Disease·H A ChapmanD S Fair
Feb 1, 1988·The American Review of Respiratory Disease·H A ChapmanL Kobzik
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·K P SteinbergL D Hudson
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·L B Ware, M A Matthay
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·K E Welty-WolfC A Piantadosi
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Renli QiaoZea Borok
Nov 2, 2004·The European Respiratory Journal·G ChoiT van der Poll
Jan 5, 2005·Nature Reviews. Immunology·Jo Rae Wright
Aug 16, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karen E Welty-WolfClaude A Piantadosi
Oct 29, 2005·American Journal of Respiratory and Critical Care Medicine·Gavin D PerkinsFang Gao
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brigitte N GompertsRobert M Strieter
Mar 4, 2006·American Journal of Respiratory Cell and Molecular Biology·Hans G Folkesson, Michael A Matthay
Nov 14, 2006·American Journal of Respiratory Cell and Molecular Biology·Ling WangLorraine B Ware
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Phillip FactorSadis Matalon
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph M PettyBenjamin T Suratt

❮ Previous
Next ❯

Citations

Mar 20, 2010·Journal of the Royal Society, Interface·Sean H J KimC Anthony Hunt
Oct 18, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Pawan K VohraDebabrata Mukhopadhyay
Sep 19, 2009·American Journal of Respiratory and Critical Care Medicine·Ulrich MattSylvia Knapp
May 2, 2012·Critical Care : the Official Journal of the Critical Care Forum·Pieter R TuinmanMarcus J Schultz
Aug 2, 2008·Critical Care : the Official Journal of the Critical Care Forum·Peter M Suter
Jun 23, 2012·PloS One·Taylor S CohenSusan S Margulies
Jul 26, 2011·Mediators of Inflammation·Ying-Gang ZhuJin-Fu Xu
Sep 15, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H KimM Liu
Aug 17, 2010·Respiratory Physiology & Neurobiology·Mônica C M ChaoPatricia R M Rocco
Oct 8, 2011·International Immunopharmacology·Kazue TakahashiMarcos F Vidal Melo
May 23, 2012·Respiratory Physiology & Neurobiology·Feng HanZhichao Li
Jul 28, 2016·Toxicon : Official Journal of the International Society on Toxinology·Vera Lucia Silva RigoniStella Regina Zamuner
Apr 14, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Frederic ChagnonOlivier Lesur
Jan 10, 2017·Disease Models & Mechanisms·Shahaf KatalanChanoch Kronman
Dec 14, 2016·ERJ Open Research·Shengxing ZhengDavid R Thickett
Oct 31, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shengxing ZhengDavid R Thickett
Dec 12, 2012·Current Opinion in Critical Care·Radu F Neamu, Greg S Martin
Jan 30, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shumin XuAlfred Ayala
Jun 29, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Duo ZhangYang Jin
Feb 22, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Manik C GhoshChristopher M Waters
Feb 14, 2018·International Journal of Molecular Medicine·Peng-Cheng LiDe-Guang Mu
Oct 25, 2020·Journal of Cellular and Molecular Medicine·Jing-Xiang YangSheng-Xing Zheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

American Journal of Physiology. Lung Cellular and Molecular Physiology
Karen E Welty-WolfClaude A Piantadosi
© 2021 Meta ULC. All rights reserved