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The Epitranscriptome and Innate Immunity

PLoS Genetics

Dec 15, 2015

Mary A O'ConnellLiam P Keegan

Abstract

Our knowledge of the variety and abundances of RNA base modifications is rapidly increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA interference, and other RNA processes, and are now increasingly detected in all types of transcripts. Can new biolo...read more

Mentioned in this Paper

Adenosine to Inosine Editing
Research
Adenosine
RNA, Untranslated
Enzymes, antithrombotic
RNA, Double-Stranded
Aminohydrolases
Inosine
Hairpin Loop Sequence
Transfer RNA
8
101
Paper Details
References
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  • Citations13
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  • References70
  • Citations13
12

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The Epitranscriptome and Innate Immunity

PLoS Genetics

Dec 15, 2015

Mary A O'ConnellLiam P Keegan

PMID: 26658668

DOI: 10.1371/journal.pgen.1005687

Abstract

Our knowledge of the variety and abundances of RNA base modifications is rapidly increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA interference, and other RNA processes, and are now increasingly detected in all types of transcripts. Can new biolo...read more

Mentioned in this Paper

Adenosine to Inosine Editing
Research
Adenosine
RNA, Untranslated
Enzymes, antithrombotic
RNA, Double-Stranded
Aminohydrolases
Inosine
Hairpin Loop Sequence
Transfer RNA
8
101

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Interferon Stimulated Genes

Interferon-stimulated gene products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. Discover the latest research on interferon-stimulated genes here.

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ADAR enzymes are responsible for a-to-i rna editing, an essential post-transcriptional rna modification contributing to transcriptome and proteome diversification.

Related Papers

Critical Reviews in Biochemistry and Molecular Biology

A-to-I editing of protein coding and noncoding RNAs

Critical Reviews in Biochemistry and Molecular BiologySeptember 20, 2012
Arka Mallela, Kazuko Nishikura
Current Issues in Molecular Biology

ADARs and the Balance Game between Virus Infection and Innate Immune Cell Response

Current Issues in Molecular BiologyDecember 17, 2014
Sara TomaselliAngela Gallo
Paper Details
References
  • References70
  • Citations13
12345...
  • References70
  • Citations13
12
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