The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy.

Theranostics
Yang ShiTwan Lammers

Abstract

Following its discovery more than 30 years ago, the enhanced permeability and retention (EPR) effect has become the guiding principle for cancer nanomedicine development. Over the years, the tumor-targeted drug delivery field has made significant progress, as evidenced by the approval of several nanomedicinal anticancer drugs. Recently, however, the existence and the extent of the EPR effect - particularly in patients - have become the focus of intense debate. This is partially due to the disbalance between the huge number of preclinical cancer nanomedicine papers and relatively small number of cancer nanomedicine drug products reaching the market. To move the field forward, we have to improve our understanding of the EPR effect, of its cancer type-specific pathophysiology, of nanomedicine interactions with the heterogeneous tumor microenvironment, of nanomedicine behavior in the body, and of translational aspects that specifically complicate nanomedicinal drug development. In this virtual special issue, 24 research articles and reviews discussing different aspects of the EPR effect and cancer nanomedicine are collected, together providing a comprehensive and complete overview of the current state-of-the-art and future directio...Continue Reading

Citations

Sep 10, 2020·International Journal of Peptide Research and Therapeutics·Chunyan LiHong Yang
Jan 17, 2021·Biomedicines·Chihiro MochizukiMichihiro Nakamura
Jan 28, 2021·Pharmaceutics·Eleen Dayana Mohamed IsaMartin R Gill
Oct 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haroon IqbalHuabing Chen
Feb 11, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Catarina Roma-RodriguesPedro V Baptista
Dec 31, 2020·Materials·Francisco SilvaAntónio Paulo
Oct 19, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jie LuoErnst Wagner
Mar 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·M GhezziS Nicoli
Mar 13, 2021·Frontiers in Chemistry·Ajita JindalAftab Alam
Mar 18, 2021·Journal of Liposome Research·Hanieh AbbasiSomayeh Handali
Mar 27, 2021·Frontiers in Oncology·Alicia S OmbredaneGraziella A Joanitti
Apr 4, 2021·Nanomaterials·Atsushi KimuraMitsumasa Taguchi
Apr 26, 2021·Advanced Drug Delivery Reviews·Marcel A HeinrichJai Prakash
Apr 30, 2021·Chemical Communications : Chem Comm·Shiqi WangHélder A Santos
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cristian ValenzuelaJianhua Zhang
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Vesna V VodnikBranka Šošić-Jurjević
Jun 1, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahsa ShahriariMona Alibolandi
Jun 3, 2021·Cancers·Soha Reda El SayedNadia Cherradi
Jun 26, 2021·Advanced Healthcare Materials·Christina Cortez-JugoFrank Caruso
Jun 16, 2021·Colloids and Surfaces. B, Biointerfaces·Huixian YanGuangxi Zhai
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
Jul 3, 2021·Antibiotics·Philip SerwerCara B Gonzales
Jul 3, 2021·Journal of Personalized Medicine·Md Abdus SubhanVladimir P Torchilin
Jul 25, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wei WuHeike E Daldrup-Link
Aug 6, 2021·Drug Delivery and Translational Research·Seung Woo ChungJung Soo Suk
Aug 11, 2021·Pharmaceutics·Jasmine L King, Soumya Rahima Benhabbour
Aug 10, 2021·Molecular Aspects of Medicine·Alysia CoxEun Ji Chung

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