PMID: 11910554Mar 23, 2002Paper

The epsilon4 allele of apolipoprotein E gene is a potential risk factor for the severity of macular edema in type 2 diabetic Mexican patients

Ophthalmic Genetics
Arturo SantosArturo Panduro

Abstract

The objective of this study was to determine the relationship between APOE polymorphism and the severity of retinal hard exudates in Mexican patients with type 2 diabetes. We studied 36 patients with diabetic retinopathy and 22 unrelated and apparently healthy age-matched individuals. Blood samples for DNA genotyping and lipid profile were taken. Genotyping of polymorphic APOE alleles was done after polymerase chain reaction amplification of genomic DNA, digestion with HhaI, and agarose gel electrophoresis. Stereoscopic 35 degrees color fundus photographs were taken of seven standard fields. Diabetic retinopathy, macular edema and hard exudates were graded according to a standardized procedure. The results showed that the lipid profile was higher but not statistically significant (p > 0.05) in e4 allele carriers, with the exception of total lipids (p > 0.05). The frequency of severe retinal hard exudates was higher in those epsilon4 allele carriers (p < 0.05). The higher frequency of visual impairment (VA < 0.5 Log MAR) in epsilon4 carriers showed a tendency towards statistical significance (p = 0.057). Our results suggest that the epsilon4 allele of the ApoE gene is a potential risk factor for the severity of retinal hard exud...Continue Reading

Citations

Apr 8, 2009·International Ophthalmology Clinics·Gerald LiewTien Y Wong
May 31, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ebony LiuKathryn Burdon
Nov 11, 2017·Journal of Personalized Medicine·Claudia Ojeda-GranadosSonia Roman
Jul 25, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F I V ErreraM R Passos-Bueno
Oct 22, 2013·Seminars in Ophthalmology·Ahmed F OmarJennifer K Sun
Oct 13, 2016·Molecular Biology Reports·Petra PriščákováVanda Repiská
Nov 11, 2017·The Journal of Clinical Endocrinology and Metabolism·Eugene J BarrettCarolina M Casellini
Dec 5, 2020·Journal of Diabetes Research·Rajya L GurungKathryn P Burdon

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