The equine gastrointestinal microbiome: impacts of weight-loss

BMC Veterinary Research
Philippa K MorrisonCaroline McGregor Argo

Abstract

Obesity is an important equine welfare issue. Whilst dietary restriction is the most effective weight-loss tool, individual animals range in their weight-loss propensity. Gastrointestinal-derived bacteria play a fundamental role in host-health and have been associated with obesity and weight-loss in other species. This study evaluated the faecal microbiome (next-generation sequencing of 16S rRNA genes) of 15 obese Welsh Mountain pony mares, in the same 11-week period across 2 years (n = 8 Year 1; n = 7 Year 2). Following a 4-week acclimation period (pre-diet phase) during which time individuals were fed the same hay to maintenance (2% body mass (BM) as daily dry matter (DM) intake), animals underwent a 7-week period of dietary restriction (1% BM hay as daily DM intake). Faeces were sampled on the final 3 days of the pre-diet phase and the final 3 days of the dietary restriction phase. Bacterial communities were determined using Next Generation Sequencing of amplified V1-V2 hypervariable regions of bacterial 16S rRNA. Losses in body mass ranged from 7.11 to 11.59%. Changes in the faecal microbiome composition following weight-loss included a reduction in the relative abundance of Firmicutes and Tenericutes and a reduction in ind...Continue Reading

References

Jul 1, 1991·The British Veterinary Journal·H A Simmons, E J Ford
Jan 1, 1993·Equine Veterinary Journal·D W PethickJ M Gooden
Jun 24, 2000·Annals of the New York Academy of Sciences·G B Forbes
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Sep 10, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S H DuncanH J Flint
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 4, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I NadalY Sanz
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Husen ZhangRosa Krajmalnik-Brown
Apr 25, 2009·Obesity·Arlette SantacruzUNKNOWN EVASYON Study Group
Jun 6, 2009·The Journal of Physiology·Peter J Turnbaugh, Jeffrey I Gordon
Jun 6, 2009·Obesity·Andreas SchwiertzPhilip D Hardt
Dec 8, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jessica K SuageeRay J Geor
Jul 9, 2010·Cytokine·Sonia EirasJosé Ramón González Juanatey
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jan Dirk van ElsasJoana Falcão Salles
Jul 17, 2012·Nature·Marcus J ClaessonPaul W O'Toole
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Nov 3, 2012·The Veterinary Journal·Caroline McG ArgoPatricia A Harris
Jan 11, 2013·FEMS Microbiology Ecology·Stefanie HandlJan S Suchodolski
Aug 30, 2013·Nature·Emmanuelle Le ChatelierOluf Pedersen
Sep 6, 2014·Journal of Nutritional Science·Megan L ShepherdWilliam S Swecker
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Jun 18, 2015·Expert Review of Gastroenterology & Hepatology·Ruchi Mathur, Gillian M Barlow
Mar 1, 2016·Frontiers in Microbiology·David Ríos-CoviánNuria Salazar
Oct 22, 2016·Acta Veterinaria Scandinavica·Rasmus B JensenAnne-Helene Tauson
Mar 14, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C MenniA M Valdes

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Citations

Apr 7, 2021·The Veterinary Clinics of North America. Equine Practice·Megan ShepherdKrishona L Martinson
Apr 30, 2021·Frontiers in Veterinary Science·Berit BoshuizenCatherine Delesalle
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Alexa C B Johnson, Amy S Biddle

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