PMID: 3753429Aug 1, 1986Paper

The equine protease inhibitory system (Pi): abnormal expressions of PiF, PiL, and PiS1

Biochemical Genetics
S D Patterson, K Bell

Abstract

Three cases of abnormal expression of the equine protease inhibitory alleles, Pi F, L, and S1, were observed following the examination of 30,000 plasma samples by one-dimensional acid (pH 4.6) polyacrylamide gel electrophoresis. Characterization of the abnormal proteins in terms of isoelectric point, molecular mass, inhibitory spectra, and sialic acid content was performed using one- and two-dimensional electrophoretic techniques. The Pi F and S1 abnormalities were postulated to be the result of amino acid substitutions causing alterations in the processing of the carbohydrate side chains. No explanation could be offered for the Pi L abnormality other than a charge shift mutation. Abnormal types, F*, L*, and S1* behaved as alleles but the distribution of L* in offspring from one stallion (present in only 6 of 83 offspring) differed significantly from expectation.

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Citations

Oct 1, 1996·Biochemical Genetics·H ArthurR A van Oorschot
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A StratilG Spik
Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J A HallidayD C Shaw
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S D Patterson
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S D PattersonD C Shaw
Jan 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D M Vankan, K Bell
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S D PattersonD C Shaw
Jan 1, 1990·Animal Genetics·S D PattersonV J Manton
Dec 1, 1995·Animal Genetics·K BellM Breen

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