The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p.

FEBS Letters
Veit GoderTom A Rapoport

Abstract

Misfolded proteins in the endoplasmic reticulum (ER) are often degraded in the cytosol by a process called ER-associated protein degradation (ERAD). During ERAD in S. cerevisiae, the ATPase Cdc48p associates with Der1p, a putative component of a retro-translocation channel. Cdc48p also binds a homolog of Der1p, Dfm1p, that has no known function in ERAD. Here, we show that Der1p and Dfm1p are contained in distinct complexes. While the complexes share several ERAD components, only the Dfm1p complex contains the Cdc48p cofactors Ubx1p and Ubx7p, while the Der1p complex is enriched in Ufd1p. These data suggest distinct functions for the Der1p and Dfm1p complexes.

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Citations

Nov 29, 2011·Nature Cell Biology·John C ChristiansonRon R Kopito
Dec 3, 2013·Nature Cell Biology·Martin MehnertErnst Jarosch
Apr 21, 2009·Molecular Biology and Evolution·Franziska HempelUwe G Maier
Oct 6, 2010·Applied Microbiology and Biotechnology·Neuza D S P CarvalhoArthur F J Ram
Jun 13, 2012·The Journal of Cell Biology·Eric M RubensteinMark Hochstrasser
Sep 19, 2014·Critical Reviews in Biochemistry and Molecular Biology·Dimitrios Zattas, Mark Hochstrasser
Sep 2, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Martin MehnertErnst Jarosch
Jul 6, 2010·Biochimica Et Biophysica Acta·Katrin BagolaThomas Sommer
Jan 5, 2011·The International Journal of Biochemistry & Cell Biology·Petek BallarFadime Aydin Kose
Apr 18, 2009·Molecular Aspects of Medicine·Tobias JungTilman Grune
Jan 25, 2019·The Journal of Biological Chemistry·Kha The NguyenCheol-Sang Hwang
Jun 25, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Veit GoderMar Bustamante-Sequeiros
Dec 15, 2020·Biochimica Et Biophysica Acta. General Subjects·Satoshi NinagawaKazutoshi Mori
Jul 10, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Rachel R Kandel, Sonya E Neal
Dec 15, 2010·Journal of Cell Science·Veit Goder, Alejandro Melero

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