The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP

Immunity
K AhnKlaus Früh

Abstract

Human cytomegalovirus (HCMV) inhibits MHC class I antigen presentation by a sequential multistep process involving a family of unique short (US) region-encoded glycoproteins. US3 retains class I molecules, whereas US2 and US11 mediate the cytosolic degradation of heavy chains by the proteosomes. In US6-transfected cells, however, intracellular transport of class I molecules is impaired because of defective peptide translocation by transporters associated with antigen processing (TAP). Peptide transport is restored in HCMV mutants lacking US6. In contrast to the cytosolic herpes simplex virus protein ICP47, US6 interacts with TAP inside the endoplasmic reticulum lumen, as shown by US6 derivatives lacking the transmembrane and cytoplasmic domains and by the observation that US6 does not prevent peptides from binding to TAP. Thus, HCMV targets TAP for immune escape by a molecular mechanism different from that of herpes simplex virus.

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Gossen, H Bujard
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y YangP A Peterson
Jul 27, 1990·Cell·A TownsendA Tse
Jan 1, 1989·Annual Review of Immunology·A Townsend, H Bodmer
Apr 1, 1982·Gene·B FleckensteinJ Collins
Nov 17, 1995·The Journal of Biological Chemistry·Y YangP A Peterson
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·M J AndrolewiczP Cresswell
Feb 1, 1996·Current Opinion in Immunology·P J Lehner, P Cresswell
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·K AhnK Früh
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·T R JonesH L Ploegh
Jan 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·K FrühP A Peterson

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Citations

Mar 29, 2002·Reviews in Medical Virology·Elke Bogner
Aug 9, 2005·Pflügers Archiv : European journal of physiology·Sandra Loch, Robert Tampé
Feb 28, 2008·Medical Microbiology and Immunology·Edward C P WallerMark R Wills
Jul 31, 2004·Current Allergy and Asthma Reports·Eric W Hewitt, Gillian E Dugan
Mar 29, 2012·Immunologic Research·Vanessa NoriegaDomenico Tortorella
Jan 16, 2014·Indian Journal of Virology : an Official Organ of Indian Virological Society·B M PratheekSubhasis Chattopadhyay
Jan 22, 2004·Current Opinion in Immunology·Paul J Lehner, Peter Cresswell
Aug 30, 2002·Molecular Immunology·Monique Grommé, Jacques Neefjes
Sep 9, 1999·Journal of Reproductive Immunology·D J SchustH L Ploegh
Sep 3, 2003·Virus Research·Aruna P N AmbagalaS Srikumaran
Jul 28, 1999·FEMS Microbiology Reviews·C Sweet
Aug 1, 1997·Current Opinion in Immunology·H Hengel, U H Koszinowski
Feb 27, 1999·Current Opinion in Immunology·D M Miller, D D Sedmak
Sep 10, 2002·Transplant Immunology·Derek MiddletonLynne Maxwell
Jun 6, 1998·Trends in Microbiology·H HengelU H Koszinowski
Sep 10, 2002·Trends in Biochemical Sciences·Peter M van EndertPaul Lehner
Jun 24, 2000·Microbes and Infection·H FarrellN Davis-Poynter
Mar 6, 1999·Current Opinion in Microbiology·M B Oldstone
Jun 7, 2012·Biochemistry·Andreas Hinz, Robert Tampé
Feb 9, 2011·Immunology and Cell Biology·Daniëlle HorstEmmanuel J H J Wiertz
Feb 9, 2011·Immunology and Cell Biology·Scott R BurrowsRajiv Khanna
Jul 21, 2010·Nature Chemical Biology·David Parcej, Robert Tampé
Feb 14, 2006·Nature Immunology·Hilary L HoareAndrew G Brooks
Jun 6, 2009·Nature Reviews. Immunology·Ted H Hansen, Marlene Bouvier
Dec 21, 2004·Nature Reviews. Microbiology·Melissa B Lodoen, Lewis L Lanier
Dec 3, 1999·Parasite Immunology·P Kaye
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ushani S RajapaksaXiao-Ning Xu
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·B E GewurzD C Wiley
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·L Coscoy, D Ganem
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·H ZhuT Shenk
Dec 19, 2007·The Journal of Biological Chemistry·Vanessa M Noriega, Domenico Tortorella
Mar 21, 1998·The Journal of Experimental Medicine·K GoldsmithR L Hendricks

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