The eradication of Helicobacter pylori to prevent gastric cancer: a critical appraisal

Expert Review of Gastroenterology & Hepatology
Jeng-Yih WuDavid Y Graham

Abstract

Gastric cancer is one of the top causes of cancer-related death worldwide. How to eliminate gastric cancer is an urgent public-health issue. Areas covered: In this review, we present up-to-date results of studies on gastric cancer prevention through the eradication of Helicobacter pylori and discuss strategies and obstacles for the implementation of population-wide screening and treatment of this pathogen to prevent gastric cancer. Expert commentary: Gastric cancer is an inflammation-associated cancer with multistep carcinogenesis. The process consists of H. pylori infection, ongoing inflammation, development of metaplastic epithelia and genetic instability eventuating in gastric cancer. H. pylori infection is critical for development of the disease and studies have consistently shown that H. pylori eradication results in a reduction in (a) gastric mucosal inflammation, (b) progression of histologic damage, (c) risk of peptic ulcers and ulcer recurrence, and (d) risk of gastric cancer. Compared with a large number of clinical trials evaluating chemopreventive approaches, studies of population-wide screening, and eradication of H. pylori have only recently begun and only in high-risk populations. To eliminate gastric cancer requ...Continue Reading

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Citations

Mar 13, 2020·Emerging Microbes & Infections·Yong XieUNKNOWN Chinese Society of Gastroenterology, Chinese Study Group on Helicobacter pylori and Peptic Ulcer
Feb 6, 2020·Current Pharmaceutical Design·Imran AliLuciana Scotti
Sep 29, 2019·World Journal of Gastroenterology : WJG·Huan LiXiao-Ming Liu
Oct 3, 2020·Gut·Jyh-Ming LiouUNKNOWN Asian Pacific Alliance on Helicobacter and Microbiota (APAHAM)
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Han YuZuguang Wu
Jun 3, 2021·International Journal of Molecular Sciences·Samantha A WhitesideCarole Creuzenet
Jun 18, 2021·Canadian Journal of Gastroenterology & Hepatology·Md ZeyaullahIrfan Ahmad
Aug 28, 2021·Journal of Clinical Medicine·Irena Mladenova
Sep 11, 2021·Digestive Diseases and Sciences·Xiaobo SongHuimin Zhou

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