PMID: 9536466Apr 16, 1998Paper

The eradication treatments of Helicobacter pylori

Pharmacy World & Science : PWS
J WermeilleM Cunningham

Abstract

The eradication of Helicobacter pylori is at present widely recognized as the adequate therapeutic approach for gastric and duodenal ulcers in infected patients. In those with dyspepsia but no ulcer as well as in those with type B chronic gastritis, eradication remains controversial. It is difficult to have a clear opinion on the advantages and disadvantages of the numerous existing therapies. Therefore, a systematic review of published treatments has been made by the authors. Ideally, the eradication treatment of H. pylori should have the following advantages: 1. eradication superior to 90%, 2. simplicity, 3. short duration, 4. safety, 5. low cost, 6. reproducibility of results. Dual therapies (2 antibiotics or a proton pump inhibitor in combination with an antibiotic) rarely allow an eradication greater than 90% and the results have poor reproducibility. Consequently, they do not represent an ideal anti-H. pylori treatment. Triple therapies come closer to the requirements for an ideal treatment, with eradication rates generally close to 90%, varying little between studies and the countries in which they were performed. The triple therapy bismuth-imidazole-tetracycline (or amoxicillin) still represents for many authors the sta...Continue Reading

Citations

Sep 9, 2010·Toxicology and Industrial Health·Hasan Turkez, Fatime Geyikoglu
Sep 28, 1999·Scandinavian Journal of Gastroenterology. Supplement·W A de Boer, E A Joosen
Jul 30, 2002·Alimentary Pharmacology & Therapeutics·P Della MonicaA Pera
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·J WermeilleA Hadengue
Mar 30, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David Y Graham, Jyh-Ming Liou

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