The ergogenic effect of recombinant human erythropoietin on VO2max depends on the severity of arterial hypoxemia.

PloS One
Paul RobachCarsten Lundby

Abstract

Treatment with recombinant human erythropoietin (rhEpo) induces a rise in blood oxygen-carrying capacity (CaO(2)) that unequivocally enhances maximal oxygen uptake (VO(2)max) during exercise in normoxia, but not when exercise is carried out in severe acute hypoxia. This implies that there should be a threshold altitude at which VO(2)max is less dependent on CaO(2). To ascertain which are the mechanisms explaining the interactions between hypoxia, CaO(2) and VO(2)max we measured systemic and leg O(2) transport and utilization during incremental exercise to exhaustion in normoxia and with different degrees of acute hypoxia in eight rhEpo-treated subjects. Following prolonged rhEpo treatment, the gain in systemic VO(2)max observed in normoxia (6-7%) persisted during mild hypoxia (8% at inspired O(2) fraction (F(I)O(2)) of 0.173) and was even larger during moderate hypoxia (14-17% at F(I)O(2) = 0.153-0.134). When hypoxia was further augmented to F(I)O(2) = 0.115, there was no rhEpo-induced enhancement of systemic VO(2)max or peak leg VO(2). The mechanism highlighted by our data is that besides its strong influence on CaO(2), rhEpo was found to enhance leg VO(2)max in normoxia through a preferential redistribution of cardiac output ...Continue Reading

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Citations

Mar 29, 2014·Medicine and Science in Sports and Exercise·Paul RobachCarsten Lundby
Jun 27, 2009·High Altitude Medicine & Biology·José A L Calbet, Carsten Lundby
Oct 6, 2010·High Altitude Medicine & Biology·Peter D Wagner
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Oct 29, 2011·Journal of Applied Physiology·Christoph SiebenmannCarsten Lundby
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