The ERMES (Endoplasmic Reticulum and Mitochondria Encounter Structures) mediated functions in fungi.

Mitochondrion
Deepika Kundu, Ritu Pasrija

Abstract

Cellular organelles are membrane-bound and provide a microenvironment for specific functions. A mitochondrion is a double membranous and dynamic organelle that undergoes numerous fusion/fission events, which depends on various cellular factors. However, it is still dependent on other organelles and requires both communications as well as the movement of physical metabolites between them. Mitochondria interact with different organelles counting lipid droplets (LD), peroxisomes, vacuoles, endoplasmic reticulum (ER) and plasma membrane (PM), etc. Apart from them, mitochondria maintain multiple interactions with ER including ERMES (Endoplasmic Reticulum and Mitochondria encounter structures). ERMES is actually a multi-protein complex, and imperative in the maintenance of mitochondrial morphology and its functions. Its disruption also compromises phospholipid exchange, drug resistance and pathogenicity. This assembly is reportedly unique to fungal systems and proposed as a target for development of new antifungal. In the light of separate reports across diverse fungal systems, we have summarised the information about its distribution and effect on mitochondrial fitness.

References

Sep 12, 2000·Molecular Biology of the Cell·H ProkischB Westermann
Mar 22, 2002·Molecular Biology of the Cell·Kai Stefan DimmerBenedikt Westermann
May 13, 2003·Cell Motility and the Cytoskeleton·Katrin V KochReinhard Fischer
Jul 25, 1956·The Journal of Biophysical and Biochemical Cytology·G E PALADE
Nov 5, 2003·The Journal of Cell Biology·Shelly Meeusen, Jodi Nunnari
Oct 14, 2004·The Journal of Cell Biology·Rebecca L FrederickJanet M Shaw
Sep 2, 2005·Molecular Biology of the Cell·Katrin Altmann, Benedikt Westermann
Jun 30, 2006·Biochimica Et Biophysica Acta·Caroline C Philpott
Dec 21, 2006·The Journal of Cell Biology·György SzabadkaiRosario Rizzuto
Oct 20, 2007·Traffic·Rebecca L Frederick, Janet M Shaw
Jun 27, 2009·Science·Benoît KornmannPeter Walter
Apr 23, 2010·Journal of Cell Science·Benoît Kornmann, Peter Walter
Nov 3, 2010·The Journal of Biological Chemistry·Koji YamanoToshiya Endo
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey M BeckerTerry Roemer
Mar 23, 2011·Journal of Aging Research·Jean-Paul DecuypereGeert Bultynck
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Benoît KornmannPeter Walter
Sep 29, 2011·Journal of Molecular Biology·David A StroudNils Wiedemann
Jan 18, 2012·Journal of Cell Science·Alexandre Toulmay, William A Prinz
Mar 23, 2012·Biochemical Society Transactions·Agnès H Michel, Benoît Kornmann
Jul 17, 2012·Journal of Cell Science·Christiane VossWilliam A Prinz
Jan 15, 2013·Journal of Proteomics·Chloe N PostonCarthene R Bazemore-Walker
Jan 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Laura L LacknerJodi Nunnari
Jun 20, 2013·Journal of Cell Science·Tao TanKai Stefan Dimmer
Nov 23, 2013·Nature Reviews. Molecular Cell Biology·Jennifer J Smith, John D Aitchison
Feb 18, 2014·Developmental Cell·Stefan Böckler, Benedikt Westermann
Feb 19, 2014·The International Journal of Biochemistry & Cell Biology·Roberto Bravo-SaguaSergio Lavandero
Jul 16, 2014·Developmental Cell·Yael Elbaz-AlonMaya Schuldiner

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Citations

Aug 9, 2020·Frontiers in Cell and Developmental Biology·Ming YangLin Sun
Oct 26, 2021·The Journal of Cell Biology·Michal Eisenberg-BordMaya Schuldiner

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