PMID: 8603044Jan 1, 1996Paper

The Ernst Schering Poster Award. Intracellular traffic of steroid hormone receptors

The Journal of Steroid Biochemistry and Molecular Biology
A Guiochon-MantelE Milgrom

Abstract

The signal responsible for the nuclear localization of the progesterone receptor has been characterized. It is a complex signal. The study of the mechanism of this nuclear localization has revealed that the receptor continuously shuttles between nucleus and the cytoplasm. The receptor diffuses into the cytoplasm and is constantly and actively transported back into the nucleus. The same phenomenon exists for estradiol and glucocorticoid receptors. The mechanism of entry of proteins into the nucleus is well documented, whereas the mechanism of their outward movement to the cytoplasm is not understood. We have grafted different nuclear localization signals (NLSs) onto beta-galactosidase and have studied the traffic of this protein using heterokaryons and microinjection experiments. We have demonstrated that the same NLSs are involved in both the inward and the outward movement of proteins through the nuclear membrane. These results suggest that the nucleocytoplasmic shuttling may be a general phenomenon for nuclear proteins that could possibly undergo modifications in the cytoplasm and exert some biological activities there. These conclusions also imply that at least part of the cellular machinery involved in the nuclear import of...Continue Reading

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Citations

Apr 19, 2002·The Journal of Biological Chemistry·Venkateshwar G KeshamouniKaladhar B Reddy
Jun 7, 2003·The Journal of Biological Chemistry·Larbi AmazitAnne Guiochon-Mantel
Jul 25, 2009·Acta Veterinaria Scandinavica·Ylva Hedberg AlmAnne-Marie Dalin
Dec 1, 2003·Acta Neuropsychiatrica·Mario F JuruenaCarmine M Pariante
May 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L PedersonM J Oursler
Jan 28, 2004·The Journal of Biological Chemistry·Jeannine BotosCatharine L Smith
Jan 13, 2005·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Mario F JuruenaCarmine M Pariante
Dec 28, 1999·Annual Review of Cell and Developmental Biology·A Kaffman, E K O'Shea
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·G Fejes-TóthA Náray-Fejes-Tóth
Jun 21, 2007·Molecular Endocrinology·Cristina T KeslerBryce M Paschal
Aug 17, 2006·FEMS Microbiology Reviews·Reena GhildyalDavid A Jans
Jun 1, 2012·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tomoe Umemoto, Yukio Fujiki
Mar 27, 2001·Molecular Endocrinology·C F BunnL A Allison
Apr 12, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Guy Leclercq
Sep 28, 1998·The Journal of Steroid Biochemistry and Molecular Biology·M BlanchereI Mowszowicz
Mar 29, 2001·Biological Psychiatry·C M Pariante, A H Miller
Jun 12, 2021·Neuroscience Letters·Mario F JuruenaAnthony J Cleare
Jan 30, 2004·Psychoneuroendocrinology·Carmine M ParianteRobert W Kerwin
Dec 17, 2005·Cancer Letters·Jennifer Prescott, Gerhard A Coetzee

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