The Erv1-Mia40 disulfide relay system in the intermembrane space of mitochondria.

Biochimica Et Biophysica Acta
Kai Hell

Abstract

The compartment between the outer and the inner membranes of mitochondria, the intermembrane space (IMS), harbours a variety of proteins that contain disulfide bonds. Many of these proteins possess a conserved twin Cx(3)C motif or twin Cx(9)C motif. Recently, a disulfide relay system in the IMS has been identified which consists of two essential components, the sulfhydryl oxidase Erv1 and the redox-regulated import receptor Mia40/Tim40. The disulfide relay system drives the import of these cysteine-rich proteins into the IMS of mitochondria by an oxidative folding mechanism. In order to enable Mia40 to perform the oxidation of substrate proteins, the sulfhydryl oxidase Erv1 mediates the oxidation of Mia40 in a disulfide transfer reaction. To recycle Erv1 into its oxidized form, electrons are transferred to cytochrome c connecting the disulfide relay system to the electron transport chain of mitochondria. Despite the lack of homology of the components, the disulfide relay system in the IMS resembles the oxidation system in the periplasm of bacteria presumably reflecting the evolutionary origin of the IMS from the bacterial periplasm.

References

May 6, 1994·Journal of Molecular Biology·D BordoM Bolognesi
Jun 14, 1996·The Journal of Biological Chemistry·D M GlerumA Tzagoloff
Sep 20, 1997·The Journal of Biological Chemistry·V C CulottaJ D Gitlin
Jan 31, 1998·The Journal of Biological Chemistry·J BeersA Tzagoloff
Feb 27, 1999·Journal of Bacteriology·F Aslund, J Beckwith
Jul 30, 1999·Nature Structural Biology·A L LambA C Rosenzweig
Jan 5, 2000·The Journal of Biological Chemistry·L HiserJ P Hosler
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·T G SenkevichB Moss
Apr 21, 2001·The Journal of Biological Chemistry·J GerberT Lisowsky
Aug 29, 2001·Nature Structural Biology·A L LambA C Rosenzweig
Sep 8, 2001·The Journal of Biological Chemistry·T NittisD R Winge
Dec 12, 2001·Nature Structural Biology·Einav GrossDeborah Fass
Feb 28, 2002·The EMBO Journal·Sean P CurranCarla M Koehler
Mar 22, 2002·Molecular Biology of the Cell·Kai Stefan DimmerBenedikt Westermann
Aug 13, 2002·The Journal of Biological Chemistry·Marina P NobregaAlexander Tzagoloff
Jan 14, 2003·Annual Review of Biochemistry·Hiroshi KadokuraJon Beckwith
Apr 30, 2003·Protein Science : a Publication of the Protein Society·Chia-Kuei WuJohn P Rose
May 16, 2003·The Journal of Biological Chemistry·Lori Sturtz FieldValeria Cizewski Culotta
Jul 29, 2003·The Journal of Biological Chemistry·Scott AllenKostas Tokatlidis
Aug 28, 2003·The EMBO Journal·Thomas LutzJohannes M Herrmann
Jan 15, 2004·The Journal of Biological Chemistry·Suzanne C Hoppins, Frank E Nargang
Jan 15, 2004·The Journal of Biological Chemistry·George T HansonS James Remington
Jan 20, 2004·Trends in Biochemical Sciences·Carla M Koehler
Feb 6, 2004·The Journal of Cell Biology·Benjamin P Tu, Jonathan S Weissman
Feb 20, 2004·The Journal of Biological Chemistry·Hui LuKostas Tokatlidis
Feb 20, 2004·The Journal of Biological Chemistry·Hui LuKostas Tokatlidis

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Citations

Aug 6, 2011·The Journal of Biological Chemistry·Lucia BanciAngelo Gallo
Jan 2, 2009·The Journal of Biological Chemistry·Bruce MorganHui Lu
Sep 4, 2010·Antioxidants & Redox Signaling·Xiang Ming Xu, Simon Geir Møller
Jan 19, 2011·Antioxidants & Redox Signaling·Stephen R ShouldiceJennifer L Martin
Dec 19, 2012·Antioxidants & Redox Signaling·Alberto Bindoli, Maria Pia Rigobello
May 30, 2009·Molecular Biology of the Cell·Heather L TiensonCarla M Koehler
Mar 20, 2009·Molecular Biology of the Cell·Dusanka MilenkovicAgnieszka Chacinska
Aug 25, 2012·Molecular Biology of the Cell·Lena BöttingerAgnieszka Chacinska
Sep 21, 2012·Molecular Biology of the Cell·Bernadette SchreinerDejana Mokranjac
Jan 2, 2013·Frontiers in Bioscience (Landmark Edition)·Matthew G Baile, Steven M Claypool
Feb 1, 2013·International Journal of Molecular Sciences·Hugo Fraga, Salvador Ventura
Jun 6, 2012·Annual Review of Biochemistry·Walter Neupert
Jan 27, 2016·Journal of Plant Physiology·Zhen-Hui Kang, Gui-Xue Wang
Dec 23, 2009·The Journal of Cell Biology·Dionisia P SiderisKostas Tokatlidis
Feb 12, 2011·FEBS Letters·Radek SzklarczykMartijn A Huynen
Feb 14, 2015·Journal of Molecular Biology·Walter Neupert
Jan 12, 2010·Trends in Endocrinology and Metabolism : TEM·Alex SheftelRoland Lill
Mar 22, 2013·Chemical Reviews·Candice E Paulsen, Kate S Carroll
Nov 3, 2015·Biochimica Et Biophysica Acta·Somsuvro BasuJulius Lukeš
Aug 26, 2009·The International Journal of Biochemistry & Cell Biology·Petr Jezek, Lydie Plecitá-Hlavatá
Sep 10, 2014·Biochimica Et Biophysica Acta·Julius Lukeš, Somsuvro Basu
Jun 23, 2011·Journal of Neurochemistry·Marjatta SonJeffrey L Elliott
Oct 20, 2011·The EMBO Journal·Max HarnerWalter Neupert
Dec 18, 2014·Protein Science : a Publication of the Protein Society·Susanne E HorvathNikolaus Pfanner
Sep 14, 2013·Plant, Cell & Environment·Xuejiao LiangHong Ye
Jul 10, 2013·The Biochemical Journal·Michael P SpillerHui Lu
Mar 4, 2014·Mitochondrion·Lucila GarciaDaniel H Gonzalez
Oct 6, 2012·Journal of Molecular Biology·Michael J BakerDiana Stojanovski
Jan 21, 2014·Biochimie·Lena K Beilschmidt, Hélène M Puccio
May 9, 2012·Biochimica Et Biophysica Acta·Pamela M SmithDennis R Winge
May 15, 2012·Biochimica Et Biophysica Acta·Diana StojanovskiAgnieszka Chacinska
Dec 6, 2011·Biochimica Et Biophysica Acta·Pamela M SmithDennis R Winge
Apr 20, 2016·Biochimica Et Biophysica Acta·Valentina StreckerIlka Wittig
Apr 22, 2008·Biochimica Et Biophysica Acta·Stuart J FergusonIan B Robertson

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