The erythroid niche: molecular processes occurring within erythroblastic islands.

Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
Narla Mohandas, Joel Anne Chasis

Abstract

Erythroblasts terminally differentiate within specialized niches composed of erythroblast islands nesting in extracellular matrix proteins. A number of adhesion molecules active in erythroid island attachments have been identified. We have recently observed a receptor/counter receptor interaction that appears to maintain island integrity: erythroid ICAM-4 interacting with macrophage alphaV integrin. When ICAM-4/alphaV binding is blocked, a 70% decrease in islands is observed. Moreover, erythroblastic islands are markedly decreased in ICAM-4 null mice. Using erythropoietin to examine whether ICAM-4/alphaV binding plays a role in stress erythropoiesis, we found that the reticulocyte response is different in ICAM-4 null mice compared to control mice. We speculate that this may be a reflection of the baseline decrease in island number in the ICAM-4 null mice. Erythroblast enucleation also occurs within the erythroid niche. Earlier, we examined whether abnormal protein sorting during nuclear extrusion creates the deficiencies of membrane proteins that are well described in hereditary spherocytosis (HS) and hereditary elliptocytosis (HE). We observed that whereas glycophorin C partitions to reticulocytes in normal mouse cells, it sor...Continue Reading

Citations

Dec 5, 2013·Physiological Reports·Zhenghui WangJohannes Vogel
Feb 5, 2011·International Journal of Hematology·Xiuli An, Narla Mohandas
Apr 6, 2013·Nature Medicine·Merav Socolovsky
Nov 27, 2019·IUBMB Life·Laura GutiérrezJohn Strouboulis
May 3, 2018·Free Radical Biology & Medicine·Chang LiaoK Sandeep Prabhu

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