The ESCRT complexes.

Critical Reviews in Biochemistry and Molecular Biology
James H Hurley

Abstract

The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0, -I, -II, -III, and Vps4-Vta1, and the ALIX homodimer. The ESCRT system is required for degradation of unneeded or dangerous plasma membrane proteins; biogenesis of the lysosome and the yeast vacuole; the budding of most membrane enveloped viruses; the membrane abscission step in cytokinesis; macroautophagy; and several other processes. From their initial discovery in 2001-2002, the literature on ESCRTs has grown exponentially. This review will describe the structure and function of the six complexes noted above and summarize current knowledge of their mechanistic roles in cellular pathways and in disease.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P GordenL Orci
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·W XieS N Cohen
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·N J Bryant, T H Stevens
Aug 11, 1998·Nature·J M GaullierR Aasland
Jul 8, 1999·Molecular Cell·T G KutateladzeM Overduin
Jan 29, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·H TakataN Kitamura
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·R N HartyF P Hayes
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·L VerPlankC A Carter
Sep 5, 2001·The EMBO Journal·C RaiborgH Stenmark
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KikonyogoJ Leis
Dec 6, 2001·Cell·S MisraJ H Hurley
Apr 23, 2002·Journal of Virology·Eric O Freed
May 4, 2002·Nature Cell Biology·Camilla RaiborgHarald Stenmark
May 15, 2002·The Journal of Biological Chemistry·Robert V StahelinWonhwa Cho
Jun 11, 2002·Nature Cell Biology·Patricia S BilodeauRobert C Piper
Dec 4, 2002·Nature Reviews. Molecular Cell Biology·David J KatzmannScott D Emr
Jan 29, 2003·The Journal of Biological Chemistry·Kristi G BacheHarald Stenmark
Feb 1, 2003·Journal of Molecular Biology·Joanna TimminsWinfried Weissenhorn

❮ Previous
Next ❯

Citations

Jun 21, 2011·Molecules and Cells·Dong-Wan KimSangho Lee
Mar 26, 2013·Trends in Cell Biology·John A SchielRytis Prekeris
Jun 30, 2012·Nature Cell Biology·James H Hurley, Greg Odorizzi
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Evzen Boura, James H Hurley
Sep 29, 2011·The Journal of Biological Chemistry·Sundaresan RajeshFedor Berditchevski
Oct 30, 2012·The Journal of Biological Chemistry·Jack J SkalickyWesley I Sundquist
Sep 28, 2012·Molecular Biology of the Cell·Seongju LeeCraig Blackstone
Apr 12, 2013·Molecular Biology of the Cell·Hong ZhuChi-Wing Chow
Jun 1, 2013·Molecular Biology of the Cell·James B Moseley
Feb 8, 2013·Genes & Development·Thierry DoanDavid Z Rudner
May 6, 2011·Journal of Virology·G N MedinaC A Carter
Jan 20, 2012·Journal of Virology·Yoshiko UsamiHeinrich G Göttlinger
Apr 17, 2012·Physiology·Anand Sitaram, Michael S Marks
Dec 4, 2012·Viruses·Sarah Katharina FehlingThomas Strecker
Apr 30, 2014·WormBook : the Online Review of C. Elegans Biology·Ken SatoBarth D Grant
Mar 27, 2013·Annual Review of Biochemistry·John McCulloughWesley I Sundquist
Mar 13, 2012·Annual Review of Biochemistry·Jason A MacGurnScott D Emr
Sep 15, 2012·Annual Review of Genetics·M JaiswalH J Bellen
Nov 3, 2014·Annual Review of Virology·Zongdi FengStanley M Lemon
Jul 27, 2012·Annual Review of Cell and Developmental Biology·Phyllis I Hanson, Anil Cashikar
Feb 19, 2013·Journal of Cell Science·Jahan YousefianThomas Klein
Feb 20, 2013·The Journal of Cell Biology·Graça Raposo, Willem Stoorvogel
Apr 29, 2015·Viruses·Yaw Shin OoiMargaret Kielian
Jul 31, 2013·The Journal of Cell Biology·Rachel AllisonEvan Reid
Jun 15, 2011·The Journal of Cell Biology·Mark C FieldMichael P Rout
Dec 17, 2015·Annual Review of Physiology·Ahmed Ibrahim, Eduardo Marbán
Feb 11, 2016·International Journal of Molecular Sciences·Hina KalraSuresh Mathivanan
Sep 24, 2015·Viruses·Marta Alenquer, Maria João Amorim
Dec 3, 2014·Current Opinion in Microbiology·Miguel A PeñalvaHerbert N Arst
Feb 26, 2016·Journal of Molecular Biology·Xin Wen, Daniel J Klionsky
Dec 4, 2012·Cellular Signalling·Adriano Marchese, Joann Trejo
Aug 31, 2011·Journal of Molecular Biology·Lorna S EhrlichCarol A Carter
Jul 19, 2011·Journal of Molecular Biology·Eric R Weiss, Heinrich Göttlinger
May 17, 2011·Current Opinion in Cell Biology·Markus Babst
Mar 2, 2016·The Journal of Cell Biology·Liliane ChristHarald Stenmark
Dec 9, 2014·Insect Biochemistry and Molecular Biology·Zhaofei Li, Gary Blissard
Feb 19, 2015·Biophysical Journal·Moritz Mercker, Anna Marciniak-Czochra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Molecular Cell Biology
James H Hurley, Phyllis I Hanson
Developmental Cell
William M HenneScott D Emr
© 2021 Meta ULC. All rights reserved