The essential functions of mitochondrial dynamics in immune cells.

Cellular & Molecular Immunology
Jia-Huan XieJin Jin

Abstract

Mitochondria are highly mobile organelles due to fission, fusion, transport, and mitophagy, and these processes are known as mitochondrial dynamics. Mitochondrial dynamics play an important role in energy production, cell division, cell differentiation, and cell death. In the past decade, numerous studies have revealed the importance of mitochondrial metabolism in immunity, and mitochondrial dynamics are essential for immune responses mediated by various cell types. In this review, we mainly discuss the role of mitochondrial dynamics in activation, differentiation, cytokine production, and the activity of related pathways in immune cells, particularly T cells, B cells, and other cells involved in the innate immune response.

References

Sep 19, 1995·Biochimica Et Biophysica Acta·E SerflingM Neumann
Jan 5, 2002·Physiological Reviews·Wulf Dröge
May 20, 2003·Immunological Reviews·Andreas KruegerPeter H Krammer
Jun 30, 2005·Journal of Cell Science·Daniel TonderaAnsgar Santel
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tianzheng YuYisang Yoon
Jun 8, 2007·The Journal of Biological Chemistry·Chuang-Rung Chang, Craig Blackstone
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ariel QuintanaMarkus Hoth
Nov 29, 2008·Immunology Letters·Edgar Abarca-RojanoF Javier Sánchez-García
Aug 20, 2009·Science Signaling·Kai YasukawaTakumi Koshiba
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian SchwindlingMarkus Hoth
Feb 9, 2010·Nature Immunology·Dale I GodfreyAlan G Baxter
Nov 13, 2010·Cellular and Molecular Life Sciences : CMLS·Franz BauernfeindVeit Hornung
Dec 3, 2010·Nature·Rongbin ZhouJürg Tschopp
Feb 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan D MichalekJeffrey C Rathmell
Mar 20, 2012·Cell Calcium·Ariel Quintana, Markus Hoth
May 24, 2012·Journal of Cell Science·William M Saxton, Peter J Hollenbeck
Aug 15, 2012·Immunological Reviews·Ruoning Wang, Douglas R Green
Jan 22, 2013·Mitochondrion·María J López-ArmadaMarta N Valcárcel-Ares
Mar 26, 2013·Nature Immunology·Christopher LupferThirumala-Devi Kanneganti
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Takeshi IchinoheYusuke Yanagi
Mar 13, 2014·The Journal of Cell Biology·Ruchika AnandThomas Langer
Apr 22, 2014·Current Opinion in Cell Biology·Suzanne Hoppins
Jul 19, 2014·Nature Reviews. Immunology·Martin GuilliamsSimon Yona
Dec 10, 2014·Nature Reviews. Neurology·Florence BurtéPatrick Yu-Wai-Man
Feb 3, 2015·Nature·A Phillip WestGerald S Shadel
Mar 19, 2015·Immunity·Samuel E WeinbergNavdeep S Chandel
May 6, 2015·The Journal of Clinical Investigation·Fritz Melchers
Aug 12, 2015·The Journal of Experimental Medicine·Michael D BuckErika L Pearce
Aug 13, 2015·Nature·Michael LazarouRichard J Youle

❮ Previous
Next ❯

Citations

Oct 26, 2020·Cell Death & Disease·Man HuangZheng Zhang
Dec 10, 2020·Immunity & Ageing : I & a·Alistair V W NunnJimmy D Bell
May 12, 2021·Cellular & Molecular Immunology·Yun ChenRongbin Zhou
Jul 3, 2021·International Journal of Molecular Sciences·Lara CoppiMaurizio Crestani

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
ubiquitination

Software Mentioned

MAVS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Diseases
Juan M Suárez-RiveroJosé A Sánchez-Alcázar
Current Opinion in Cell Biology
Daniela Senft, Ze'ev A Ronai
Antioxidants & Redox Signaling
Sang-Bing OngDerek J Hausenloy
Biochimica Et Biophysica Acta. Molecular Cell Research
Jinliang NanJian'an Wang
© 2022 Meta ULC. All rights reserved