The Essential Oil of Cymbopogon citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-Induced Breast Cancer in Female Rats.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Juan Pedro Rojas-ArmasJulio Hilario-Vargas

Abstract

C. citratus essential oil and carvacrol have shown an antitumor effect on breast tumor cell lines; the main objective of this research was to evaluate the antitumor effect of the essential oil of Cymbopogon citratus (EOCc) and carvacrol on 7,12-dimethylbenz [a] anthracene (DMBA)-induced breast cancer in female rats. Cancer was induced by a single administration of DMBA at dose of 80 mg/kg body weight (BW). A total of 54 female Holtzman rats were randomly assigned into 9 groups (n = 6). Group I: PS (Physiological saline); Group II: DMBA; Groups III, IV, and V: DMBA + EOCc at doses of 50, 100 and 200 mg/kg/day BW, respectively; Groups VI, VII, and VIII: DMBA + carvacrol at doses of 50, 100 and 200 mg/kg/day BW, respectively; and group IX: DMBA + EOCc + carvacrol at doses of 100 mg/kg/day BW. The treatment lasted 14 weeks. As results, EOCc showed a reduction in tumors as well as necrosis and mitosis. Animals treated with carvacrol did not show necrosis, mitosis, or infiltration. Carvacrol at dose of 100 mg/kg/day BW revealed a significant decrease in the cumulative tumor volume down to 0.11 ± 0.05 cm3 compared to 0.38 ± 0.04 cm3 of the DMBA group (p < 0.01). It is concluded that EOCc and carvacrol had an antitumor effect on DMBA-i...Continue Reading

References

Jun 3, 2005·Planta medica·Nativ DudaiRivka Ofir
Dec 13, 2006·BMC Complementary and Alternative Medicine·Kathryn A VickersSheila M Greenfield
Apr 14, 2007·Laboratory Animals·J A SmithUNKNOWN FELASA Working Group on Ethical Evaluation of Animal Experiments
Aug 7, 2009·Fundamental & Clinical Pharmacology·Wahid ChaoukiMohamed Hmamouchi
Jan 26, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·K M Arunasree
Mar 20, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Monalisa Ribeiro SilvaGlauce Socorro de Barros Viana
Jun 15, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·I H N BassoléM H Dicko
Sep 1, 2011·Molecular and Cellular Biochemistry·Subramaniyan JayakumarThiruvengadam Devaki
Oct 10, 2013·Journal of Palliative Medicine·Deniz ArslanEmre Akar
May 3, 2014·BioMed Research International·Mohammed F Halabi, Bassem Y Sheikh
Sep 23, 2014·The Libyan Journal of Medicine·Mohamed Nadjib BoukhatemHadjer Tchoketch Kebir
Apr 25, 2015·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Zeneida Teixeira PintoMargareth Maria de Carvalho Queiroz
Feb 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Elizabeth S McDonaldGary M Freedman
Sep 7, 2016·Molecular Oncology·Margaret Lois ThomasPaola Marcato
Sep 10, 2016·Journal of the Science of Food and Agriculture·Luis A Ortega-RamirezJ Fernando Ayala-Zavala
Nov 9, 2016·Maturitas·Raúl Baena Ruiz, Pedro Salinas Hernández
Jan 18, 2017·Phytotherapy Research : PTR·Akash TariqMuhammad Adnan
Jan 1, 2014·The Libyan Journal of Medicine·Mohamed Nadjib BoukhatemHadjer Tchoketch Kebir
May 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kalyani Chowdary KarnamMangala Lahkar
Jun 8, 2017·Seminars in Cell & Developmental Biology·Jennifer N Moloney, Thomas G Cotter
Feb 13, 2018·BMC Complementary and Alternative Medicine·Siyamak Ebrahimi NigjehRozita Rosli
May 17, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·K BlowmanI M Pires
May 2, 2019·Breast Cancer : Targets and Therapy·Zohre Momenimovahed, Hamid Salehiniya
Jul 26, 2019·Toxicological Research·Juan Rojas-ArmasOscar Herrera-Calderón

❮ Previous
Next ❯

Citations

Dec 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Halina Maria Ekiert, Agnieszka Szopa
Nov 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Oscar Herrera-CalderonVidalina Andía-Ayme
May 6, 2021·International Journal of Molecular Sciences·Mariola Zielińska-BłajetJoanna Feder-Kubis
Jul 27, 2021·Frontiers in Pharmacology·Laeza Alves SampaioAdriana Gibara Guimarães
Aug 10, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Marie Alfrede MvondoSylvie Léa Wansi Ngnokam
Nov 12, 2021·Journal of Complementary & Integrative Medicine·Marie Alfrede MvondoSylvie Léa Wansi Ngnokam

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.