PMID: 46337Jan 4, 1975

The essential role of glucagon in the pathogenesis of diabetes mellitus

Lancet
Roger H Unger, L Orci

Abstract

The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycaemia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time. These facts are compatible with a bihormonal-abnormality hypothesis, which holds that the major consequence of absolute or relative insulin lack is glucose underutilisation and that absolute or relative glucagon excess is the principal factor in the over-production of glucose in diabetes.

References

Jan 12, 2002·Biochemical and Biophysical Research Communications·Janice C ParkerJohn D McNeish
Jan 1, 1981·Diabetologia·Roger H Unger
Oct 1, 1975·Diabetologia·V Leclercq-MeyerR Leclercq
Dec 1, 1976·Diabetologia·M L VillanuevaJ Marco
Dec 1, 1976·Diabetologia·J Ludvigsson, L G Heding
Dec 1, 1975·Diabetologia·A S LuyckxP J Lefebvre
Jun 1, 1979·Diabetologia·P J Lefebvre, A S Luyckx
May 1, 1978·Acta diabetologica latina·A TiengoG Crepaldi
Aug 30, 2008·Science in China. Series C, Life Sciences·C WenS Zhu
Apr 6, 2011·Diabetologia·J C Henquin, J Rahier
May 1, 1980·Injury·D P Cuthbertson
Dec 12, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R Guardado-MendozaF Folli
Apr 28, 1977·The New England Journal of Medicine·Roger H Unger
Jun 2, 1977·The New England Journal of Medicine·A J BarnesD J Chisholm
Sep 8, 1977·The New England Journal of Medicine·Roger H Unger
Aug 31, 1978·The New England Journal of Medicine·P Raskin, Roger H Unger
Jun 25, 1981·The New England Journal of Medicine·Roger H Unger, L Orci
Aug 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Helga EllingsgaardMarc Y Donath
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xinxin YuRoger H Unger
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Young LeeRoger H Unger

Citations

Jul 1, 1975·The Journal of Clinical Investigation·H SasakiRoger H Unger
Feb 14, 1975·Science·R DobbsRoger H Unger
Apr 26, 1974·Science·D J KoerkerC C Gale
May 1, 1974·Endocrinology·W D HarveyRoger H Unger
Jan 1, 1969·Diabetes·A OhnedaRoger H Unger
Jan 1, 1980·Annual Review of Biochemistry·J D McGarry, D W Foster
May 1, 1972·Diabetes·Roger H UngerW A Muller

Related Concepts

Pathogenic Aspects
Glucagon (rDNA)
Pathogenesis
Depressive Disorder
Glucose, (beta-D)-Isomer
Abufne
Glucagon
Glucagon Measurement
Malnutrition
Streptozotocin Diabetes

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.