The essentiality of non-coding RNAs in cell reprogramming

Non-coding RNA Research
Joachim LuginbühlJay W Shin

Abstract

In mammals, short (mi-) and long non-coding (lnc) RNAs are immensely abundant and they are proving to be more functional than ever before. Particularly in cell reprogramming, non-coding RNAs are essential to establish the pluripotent network and are indispensable to reprogram somatic cells to pluripotency. Through systematic screening and mechanistic studies, diverse functional features of both miRNA and lncRNAs have emerged as either scaffolds, inhibitors, or co-activators, necessary to orchestrate the intricacy of gene regulation. Furthermore, the collective characterizations of both miRNA and lncRNA reveal their interdependency (e.g. sequestering the function of the other) to modulate cell reprogramming. This review broadly explores the regulatory processes of cell reprogramming - with key functional examples in neuronal and cardiac differentiations - in the context of both short and long non-coding RNAs.

Citations

Nov 28, 2018·Journal of Cellular Physiology·Behnaz TaheriNosratollah Zarghami
Dec 12, 2018·Journal of Cellular Physiology·Javad Amini MahabadiAmirhosein Sahebkar
Jan 8, 2020·International Journal of Molecular Sciences·Enrico AlessioStefano Cagnin
Dec 4, 2020·Pharmaceuticals·Ilaria GuerrieroArturo Orlacchio
Feb 24, 2021·Nature Reviews. Molecular Cell Biology·Haofei WangLi Qian
Apr 10, 2021·Essays in Biochemistry·Chi Wai YipJay W Shin
May 24, 2020·Genomics, Proteomics & Bioinformatics·Shahzina KanwalXichen Bao
Nov 22, 2020·Seminars in Cancer Biology·Homa FatmaHifzur R Siddique

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Methods Mentioned

BETA
transfection
acetylation
immunoprecipitation

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